Telomere Length as a Marker of Suicidal Risk in Schizophrenia

Schizophrenia and suicidal behavior are associated with shortening in the length of telomeres. The aim of the study was to compare the content (pg/mcg) of telomeric repeat in DNA isolated from peripheral blood cells in three groups of subjects: patients with schizophrenia and a history of suicide at...

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Bibliographic Details
Published in:Consortium psychiatricum (English ed. Online) 2022, Vol.3 (2), p.37-47
Main Authors: Zakharova, Natalia, Bravve, Lidia, Mamedova, Galina, Kaydan, Maria, Ershova, Elizaveta, Martynov, Andrey, Veiko, Natalia, Kostyuk, Svetlana
Format: Article
Language:English
Subjects:
mtdna
schizophrenia
suicide
telomere length
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Summary:Schizophrenia and suicidal behavior are associated with shortening in the length of telomeres. The aim of the study was to compare the content (pg/mcg) of telomeric repeat in DNA isolated from peripheral blood cells in three groups of subjects: patients with schizophrenia and a history of suicide attempts, patients with schizophrenia without suicidal tendencies, and healthy control volunteers. Relapses according to gender and age were examined in 47 patients with schizophrenia with suicidal behavior, 47 patients without self-destructive conditions, and 47 volunteers with healthy control and maintenance for the content of telomeric and the number of copies of mitochondrial DNA (mtDNA) in peripheral blood leukocytes. Analysis of determining the content of telomeric repeat (TR) in the DNA of massive weight gain in the series: patients with schizophrenia and suicidal attempts - patients with schizophrenia without suicidal observations - healthy controls (225±28.4 (227 [190; 250]) vs. 243±21 (245 [228; 260]) vs. 255±17.9 (255 [242; 266]),
ISSN:2712-7672
2713-2919
2713-2919
DOI:10.17816/CP171