Treatment of Sjögren's Syndrome with Mesenchymal Stem Cells: A Systematic Review

Mesenchymal stem cells (MSCs) are ubiquitous in the human body. Mesenchymal stem cells were initially isolated from bone marrow and later from other organs such as fatty tissues, umbilical cords, and gingiva. Their secretory capacities give them interesting immunomodulatory properties in cell therap...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-09, Vol.22 (19), p.10474
Main Authors: Chihaby, Najwa, Orliaguet, Marie, Le Pottier, Laëtitia, Pers, Jacques-Olivier, Boisramé, Sylvie
Format: Article
Language:English
Subjects:
Autoimmune diseases
Bone marrow
Cell therapy
Chronic Disease
Cytokines
Cytokines - metabolism
Dendritic cells
Disease
Exocrine glands
Growth factors
Humans
Immunomodulation
Inflammation - metabolism
Inflammation - pathology
Inflammation - therapy
Intravenous administration
Lacrimal gland
Lymphocytes
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Mesenchymal Stem Cells - pathology
oral sicca
Organs
Peritoneum
Review
Rheumatoid arthritis
Salivary gland
Salivary glands
Salivary Glands - metabolism
Salivary Glands - pathology
Secretions
Sjogren's syndrome
Sjogren's Syndrome - metabolism
Sjogren's Syndrome - prevention & control
Sjogren's Syndrome - therapy
Sjögren’s syndrome
Stem cell transplantation
Stem cells
Systematic review
Tumor necrosis factor-TNF
Umbilical cord
xerostomia
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Summary:Mesenchymal stem cells (MSCs) are ubiquitous in the human body. Mesenchymal stem cells were initially isolated from bone marrow and later from other organs such as fatty tissues, umbilical cords, and gingiva. Their secretory capacities give them interesting immunomodulatory properties in cell therapy. Some studies have explored the use of MSCs to treat Sjögren's syndrome (SS), a chronic inflammatory autoimmune disease that mainly affects exocrine glands, including salivary and lacrimal glands, although current treatments are only palliative. This systematic review summarizes the current data about the application of MSCs in SS. Reports show improvements in salivary secretions and a decrease in lymphocytic infiltration in salivary glands in patients and mice with SS after intravenous or infra-peritoneal injections of MSCs. MSC injections led to a decrease in inflammatory cytokines and an increase in anti-inflammatory cytokines. However, the intrinsic mechanism of action of these MSCs currently remains unknown.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms221910474