Fluoride levels and osteosarcoma

Abstract Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. Aims: The present study was planned to analyze serum levels of fluoride in patients of...

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Bibliographic Details
Published in:South Asian journal of cancer 2012-10, Vol.1 (2), p.76-77
Main Authors: Kharb, Simmi, Sandhu, Ravindra, Kundu, Zile Singh
Format: Article
Language:English
Subjects:
Fluoride
Original
Original Article
osteosarcoma
serum
water
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Summary:Abstract Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. Aims: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water. Settings and Design: The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls). Materials and Methods: Serum and drinking water fluoride levels were estimated by ion selective electrode. Statistical analysis used: The data were computed as mean ± SD and Student’s t test was applied. Results: Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P < 0.05, P < 0.001, respectively). Conclusions: These results suggest a link between fluoride exposure and osteosarcoma.
ISSN:2278-330X
2278-4306
DOI:10.4103/2278-330X.103717