Integrated Predictors by Propensity Scoring With Tumor Markers and Plasma Levels of microRNA-21-5p, IL-17, and IL-10 Complement Early Detection of Hepatocellular Carcinoma in Patients With Liver Cirrhosis

Objectives: The clinical usefulness of tumor markers alpha-fetoprotein (AFP) and des-gamma carboxyprothrombin (DCP) in the early detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC), including those with marker decline after antiviral therapy, is limited. MicroRNAs (miRN...

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Published in:Technology in cancer research & treatment 2023-01, Vol.22, p.15330338231212084-15330338231212084
Main Authors: Machida, Maiko, Ambo, Mayuko, Mishina, Runa, Hada, Nanaka, Tachibana, Fuhito, Yamashita, Miki, Konda, Ainari, Tsuji, Kunihiko
Format: Article
Language:English
Subjects:
alpha-Fetoproteins
Antiviral agents
Biomarkers
Biomarkers, Tumor
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - genetics
Cirrhosis
Hepatocellular carcinoma
Humans
Interleukin 10
Interleukin 17
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis - diagnosis
Liver Cirrhosis - genetics
Liver Neoplasms - etiology
Liver Neoplasms - genetics
MicroRNAs
MicroRNAs - genetics
miRNA
Pilot Projects
Plasma levels
Prospective Studies
Protein Precursors
Prothrombin
ROC Curve
Surveillance
Tumor markers
Tumors
α-Fetoprotein
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Summary:Objectives: The clinical usefulness of tumor markers alpha-fetoprotein (AFP) and des-gamma carboxyprothrombin (DCP) in the early detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC), including those with marker decline after antiviral therapy, is limited. MicroRNAs (miRNAs) are expected to complement detection; however, their details remain unknown. Our prospective pilot study aimed to improve the surveillance of HCC high-risk LC patients by propensity scoring with tumor markers and additional predictors. Methods: Tumor markers and plasma levels of cytokines and miRNAs were observationally measured and statistically evaluated with propensity scoring in 85 eligible patients: 43 with current HCC (cHCC) including 8 with early-HCC, 22 with previous HCC cured (pHCC), and 20 with intact LC (iLC). Results: The analysis of the area under the receiver operating characteristic curve (AUC) showed that the best single predictor was AFP (0.794 for cHCC-discrimination and 0.771 for pHCC-discrimination). AFP−DCP integrated with miR-21-5p for cHCC-discrimination was 0.896; with IL-10 for pHCC-discrimination was 0.872, these were significantly better than those of AFP alone, independently (P 
ISSN:1533-0346
1533-0338
DOI:10.1177/15330338231212084