Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem cells, including osteochondral and adipocyte progenitors. Nevertheless, the identification and classification are still controver...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-01, Vol.9, p.787118-787118
Main Authors: Gao, Qianmin, Wang, Lipeng, Wang, Sicheng, Huang, Biaotong, Jing, Yingying, Su, Jiacan
Format: Article
Language:English
Subjects:
adipocyte lineage cells
BMSC
bone marrow mesenchymal stromal cells
Cell and Developmental Biology
multipotent stem cells
skeletal stem cells
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Summary:Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem cells, including osteochondral and adipocyte progenitors. Nevertheless, the identification and classification are still controversial, which limits their application. In recent years, by lineage tracing and single-cell sequencing, several new subgroups of BMSCs and their roles in normal physiological and pathological conditions have been clarified. Key regulators and mechanisms controlling the fate of BMSCs are being revealed. Cross-talk among subgroups of bone marrow mesenchymal cells has been demonstrated. In this review, we focus on recent advances in the identification and classification of BMSCs, which provides important implications for clinical applications.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.787118