Acetylene in Organic Synthesis: Recent Progress and New Uses

Recent progress in the leading synthetic applications of acetylene is discussed from the prospect of rapid development and novel opportunities. A diversity of reactions involving the acetylene molecule to carry out vinylation processes, cross-coupling reactions, synthesis of substituted alkynes, pre...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-09, Vol.23 (10), p.2442
Main Authors: Voronin, Vladimir V, Ledovskaya, Maria S, Bogachenkov, Alexander S, Rodygin, Konstantin S, Ananikov, Valentine P
Format: Article
Language:English
Subjects:
acetylene
Acetylene - chemistry
addition reactions
Alkynes - chemical synthesis
Alkynes - chemistry
biologically active molecule
cross-coupling
Drug Design
drugs
Molecular Structure
monomers
Pharmaceutical Preparations - chemical synthesis
Pharmaceutical Preparations - chemistry
pharmaceutical substances
polymers
Review
vinylation
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Summary:Recent progress in the leading synthetic applications of acetylene is discussed from the prospect of rapid development and novel opportunities. A diversity of reactions involving the acetylene molecule to carry out vinylation processes, cross-coupling reactions, synthesis of substituted alkynes, preparation of heterocycles and the construction of a number of functionalized molecules with different levels of molecular complexity were recently studied. Of particular importance is the utilization of acetylene in the synthesis of pharmaceutical substances and drugs. The increasing interest in acetylene and its involvement in organic transformations highlights a fascinating renaissance of this simplest alkyne molecule.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23102442