Electrochemical vicinal oxyazidation of α-arylvinyl acetates

α-Azidoketones are valuable and versatile building blocks in the synthesis of various bioactive small molecules. Herein, we describe an environmentally friendly and efficient electrochemical vicinal oxyazidation protocol of α-arylvinyl acetates to afford diverse α-azidoketones in good yields without...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2022-08, Vol.18 (1), p.1026-1031
Main Authors: Li, Yi-Lun, Shi, Zhaojiang, Shen, Tao, Ye, Ke-Yin
Format: Article
Language:English
Subjects:
Acetic acid
azide
azidoketone
Chemistry
electrosynthesis
enol acetate
Letter
Oxidants
Oxidation
radical
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Summary:α-Azidoketones are valuable and versatile building blocks in the synthesis of various bioactive small molecules. Herein, we describe an environmentally friendly and efficient electrochemical vicinal oxyazidation protocol of α-arylvinyl acetates to afford diverse α-azidoketones in good yields without the use of a stoichiometric amount of chemical oxidant. A range of functionality is shown to be compatible with this transformation, and further applications are demonstrated.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.18.103