Chronic hypersensitivity pneumonitis

Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and...

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Bibliographic Details
Published in:Journal of asthma and allergy 2016-01, Vol.9, p.171-181
Main Authors: Pereira, Carlos Ac, Gimenez, Andréa, Kuranishi, Lilian, Storrer, Karin
Format: Article
Language:English
Subjects:
Airway management
Alveoli
Alveolitis
Antigens
Bronchus
Care and treatment
Cluster analysis
Cytokines
Development and progression
Differential diagnosis
Disease susceptibility
Extrinsic allergic alveolitis
Fibrosis
Hypersensitivity
Hypersensitivity pneumonitis
Inflammation
Inhalation
Lung diseases
Lung transplantation
Medical prognosis
Organ transplantation
Peptides
Pneumonia
Pneumonitis
Prognosis
Pulmonary fibrosis
Pulmonary function tests
Respiratory function
Review
Tomography
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Description
Summary:Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary.
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S81540