Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection

Whether, and how, cardioprotective effects of antiretroviral treatment (ART) in adolescents with perinatal HIV infection (APHIV) vary with age at treatment initiation is unknown. We used magnetic resonance imaging to compare cardiac status between APHIV initiated on ART at 

Saved in:
Bibliographic Details
Published in:Scientific reports 2024-06, Vol.14 (1), p.14234-10, Article 14234
Main Authors: Magodoro, Itai M., Guerrero-Chalela, Carlos E., Claggett, Brian, Jermy, Stephen, Samuels, Petronella, Myer, Landon, Zar, Heather J, Jao, Jennifer, Ntsekhe, Mpiko, Siedner, Mark J., Ntusi, Ntobeko A. B.
Format: Article
Language:English
Subjects:
692/4019
692/4019/592
692/499
692/699/255/1901
Adolescence
Adolescent
Adolescents
Age
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - administration & dosage
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral therapy
ART initiation
Cardio-protection
Child
Child, Preschool
CMR
Female
Fibrosis
Heart
HIV
HIV Infections - drug therapy
HIV-1 - drug effects
Human immunodeficiency virus
Humanities and Social Sciences
Humans
Infectious Disease Transmission, Vertical - prevention & control
Magnetic Resonance Imaging
Male
multidisciplinary
Phenotypes
PHIV
Science
Science (multidisciplinary)
Standard scores
Teenagers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whether, and how, cardioprotective effects of antiretroviral treatment (ART) in adolescents with perinatal HIV infection (APHIV) vary with age at treatment initiation is unknown. We used magnetic resonance imaging to compare cardiac status between APHIV initiated on ART at 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-65119-9