Evaluation of laboratory markers of progression of HIV disease to death

• Published in: Revista da Sociedade Brasileira de Medicina Tropical 2011-11, Vol.44 (6), p.657-660
• Main Authors: Viana, Graça Maria de Castro, Nascimento, Maria do Desterro Soares Brandão, Ferreira, Aila de Menezes, Rabelo, Érica Milena Fernandes, Diniz Neto, João Arnaud, Galvão, Carolina de Souza, Santos, Alessandro Carvalho dos, Santos Júnior, Onildo Martins, Oliveira, Rodrigo Artur Souza de, Binda Júnior, José Roberto
• Format: Article
• Language: English
• Subjects: Adult; Alanine Transaminase - blood; Antiretroviral agents; Aspartate Aminotransferases - blood; Biomarkers - blood; CD4 Lymphocyte Count; Disease Progression; Fatores de risco; Female; Hemoglobin A - metabolism; HIV Infections - blood; HIV Infections - immunology; HIV Infections - mortality; HIV/AIDS; Humans; Laboratory tests; Lymphocytes; Male; Prognosis; Prognóstico; Retrospective Studies; Sexually transmitted diseases; Statistical analysis; STD; Survival Analysis; TROPICAL MEDICINE; Viral Load; Young Adult
• ISSN: 0037-8682; 1678-9849; 1678-9849
• DOI: 10.1590/S0037-86822011005000062

One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. The sample included 100 patients--57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.