Effect of prior depression diagnosis on bipolar disorder outcomes: A retrospective cohort study using a medical claims database

Background Bipolar disorder often emerges from depressive episodes and is initially diagnosed as depression. This study aimed to explore the effects of a prior depression diagnosis on outcomes in patients diagnosed with bipolar disorder. Methods This cohort study analyzed data of patients aged 18–64...

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Bibliographic Details
Published in:Neuropsychopharmacology reports 2024-09, Vol.44 (3), p.591-598
Main Authors: Sakurai, Hitoshi, Nakashima, Masayuki, Tsuboi, Takashi, Baba, Kenji, Nosaka, Tadashi, Watanabe, Koichiro, Kawakami, Koji
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - epidemiology
Cohort Studies
Databases, Factual - trends
depression
Depression - diagnosis
Depression - epidemiology
diagnosis
Female
Hospitalization - trends
hospitalization rate
Humans
Japan - epidemiology
Male
Middle Aged
Mortality
Original
Psychotropic drugs
Retrospective Studies
Young Adult
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Summary:Background Bipolar disorder often emerges from depressive episodes and is initially diagnosed as depression. This study aimed to explore the effects of a prior depression diagnosis on outcomes in patients diagnosed with bipolar disorder. Methods This cohort study analyzed data of patients aged 18–64 years who received a new bipolar disorder diagnosis in Japan, using medical claims data from January 2005 to October 2020 provided by JMDC, Inc. The index month was defined as the time of the bipolar diagnosis. The study assessed the incidence of psychiatric hospitalization, all‐cause hospitalization, and mortality, stratified by the presence of a preceding depression diagnosis and its duration (≥1 or
ISSN:2574-173X
2574-173X
DOI:10.1002/npr2.12457