Clear cell gynecologic carcinomas: about 5 cases

Clear cell carcinoma (CCC) can simulate yolk sac tumor if the location is ovarian. In this case, the morphological distinction between these tumors is often difficult, but immunohistochemistry, the determination of CA125, of alpha fetoprotein (AFP) and the response to chemotherapy are particularly u...

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Bibliographic Details
Published in:The Pan African medical journal 2019-10, Vol.34 (87), p.87
Main Authors: Haifa, Bergaoui, Ines, Zouari, Manel, Njima, Amira, Daldoul, Sonia, Zaied, Laila, Njim, Houda, Mhabrech, Anis, Hadded, Raja, Felah
Format: Article
Language:English
Subjects:
Abdomen
Adenocarcinoma, Clear Cell - diagnosis
Adenocarcinoma, Clear Cell - pathology
Adenocarcinoma, Clear Cell - therapy
Adult
Aged, 80 and over
alpha-Fetoproteins - analysis
CA-125 Antigen - analysis
Case Series
Chemotherapy
clear cell carcinoma
Cysts
Diagnosis, Differential
Endodermal Sinus Tumor - diagnosis
Endodermal Sinus Tumor - pathology
Endometrial cancer
Female
Genital cancers
Genital Neoplasms, Female - diagnosis
Genital Neoplasms, Female - pathology
Genital Neoplasms, Female - therapy
gynecologic carcinoma
Gynecology
Histology
Humans
Hypertension
Localization
Lymphatic system
Magnetic resonance imaging
Middle Aged
Ovarian cancer
Pain
Prognosis
Radiation therapy
Retrospective Studies
surgery
Ultrasonic imaging
Vagina
Womens health
Young Adult
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Summary:Clear cell carcinoma (CCC) can simulate yolk sac tumor if the location is ovarian. In this case, the morphological distinction between these tumors is often difficult, but immunohistochemistry, the determination of CA125, of alpha fetoprotein (AFP) and the response to chemotherapy are particularly useful for solving this differential diagnosis problem. Endometrial and vaginal localization is even rare and appears to be related to distilbene uptake for vaginal localization. Whatever the gynecological location, CCC seems to have a poor prognosis. We report 5 cases of gynecological CCC including 1 case of vaginal carcinoma, 1 case of endometrial carcinoma and 3 cases of ovarian carcinoma. The definitive pathological examination concluded with the CCC diagnosis for all cases. Our purpose is to report these rare cases, their diagnosis, prognosis and therapeutic management.
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2019.34.87.18505