Significance of Ubiad1 for Epidermal Keratinocytes Involves More Than CoQ10 Synthesis: Implications for Skin Aging

The significance of Coenzyme Q10 (CoQ10) as an anti-oxidant barrier of the skin, as well as a key component in anti-aging strategies for skin care products, has been firmly established. Biosynthesis of CoQ10 in the mitochondria is well known, but there is only limited information on the non-mitochon...

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Bibliographic Details
Published in:Cosmetics (Basel) 2018-03, Vol.5 (1), p.9
Main Authors: Labarrade, Florian, Menon, Gopinathan, Labourasse, Laura, Gondran, Catherine, Cucumel, Karine, Domloge, Nouha
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Biosynthesis
Coenzyme Q10
Electron microscopy
Enzymes
Epidermis
Fluidity
Gene expression
Golgi apparatus
Immunoglobulins
keratinocyte
Keratinocytes
Lipid peroxidation
Lipids
Localization
Membrane fluidity
Mitochondria
Oxidation
Oxidative stress
Peptides
Preservation
Reactive oxygen species
Skin
Tumor suppressor genes
Ubiad1
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Summary:The significance of Coenzyme Q10 (CoQ10) as an anti-oxidant barrier of the skin, as well as a key component in anti-aging strategies for skin care products, has been firmly established. Biosynthesis of CoQ10 in the mitochondria is well known, but there is only limited information on the non-mitochondrial synthesis of CoQ10 in the skin. Recent findings in zebrafish identified that a tumor suppressor, Ubiad1, is also a key enzyme in the non-mitochondrial synthesis of CoQ10. The purpose of this study was to investigate expression of Ubiad1 in human skin, and its implication in the skin’s cutaneous response to oxidative stress. We observed Ubiad1 localization in the epidermis, particularly a subcellular localization in the Golgi apparatus. Ubiad1 modulation by a pentapeptide was associated with an observed reduction in ROS/RNS stresses (−44%/−19% respectively), lipid peroxidation (−25%) and preservation of membrane fluidity under stress conditions. Electron microscopy of keratinocytes revealed a significant degree of stimulation of the Golgi complex, as well as significantly improved mitochondrial morphology. Given the importance of CoQ10 in mitigating the visible signs of skin aging, our findings identify Ubiad1 as an essential component of the defensive barriers of the epidermis.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics5010009