Development of spray-dried powder hand sanitiser with prolonged effectivity

Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some produc...

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Bibliographic Details
Published in:Scientific reports 2024-02, Vol.14 (1), p.4827-4827, Article 4827
Main Authors: Večerková, Lucie, Mašková, Lucie, Knejzlík, Zdeněk, Kašpar, Ondřej, Tokárová, Viola
Format: Article
Language:English
Subjects:
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Alcohol use
Antimicrobial agents
Chitosan
Chlorhexidine
Controlled release
COVID-19
Disinfectants
E coli
Ethanol
Hands
Health problems
Humanities and Social Sciences
Hygiene
Irritation
multidisciplinary
Nanoparticles
Pandemics
Pathogens
Personal hygiene
Public health
Sanitizers
Science
Science (multidisciplinary)
Skin
Topology
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Summary:Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-55503-w