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Development of spray-dried powder hand sanitiser with prolonged effectivity
Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some produc...
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| Published in: | Scientific reports 2024-02, Vol.14 (1), p.4827-4827, Article 4827 |
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| creator | Večerková, Lucie Mašková, Lucie Knejzlík, Zdeněk Kašpar, Ondřej Tokárová, Viola |
| description | Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d |
| doi_str_mv | 10.1038/s41598-024-55503-w |
| format | article |
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E.
coli
and
S.
epidermidis
. The real-life performance was investigated with twelve volunteers performing various activities for up to 2 h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers’ fingers concerning the total amount of adhered and detached particles.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-024-55503-w</identifier><identifier>PMID: 38413707</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/22/1294 ; 639/166/898 ; 639/301/54/152 ; 692/700 ; 692/700/459 ; 692/700/478/174 ; Alcohol use ; Antimicrobial agents ; Chitosan ; Chlorhexidine ; Controlled release ; COVID-19 ; Disinfectants ; E coli ; Ethanol ; Hands ; Health problems ; Humanities and Social Sciences ; Hygiene ; Irritation ; multidisciplinary ; Nanoparticles ; Pandemics ; Pathogens ; Personal hygiene ; Public health ; Sanitizers ; Science ; Science (multidisciplinary) ; Skin ; Topology</subject><ispartof>Scientific reports, 2024-02, Vol.14 (1), p.4827-4827, Article 4827</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c492t-5c8803bd0bc17474fb018eded7a05541520c8c176dc1ad463ed801838d9e1b693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2932319988/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2932319988?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38413707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Večerková, Lucie</creatorcontrib><creatorcontrib>Mašková, Lucie</creatorcontrib><creatorcontrib>Knejzlík, Zdeněk</creatorcontrib><creatorcontrib>Kašpar, Ondřej</creatorcontrib><creatorcontrib>Tokárová, Viola</creatorcontrib><title>Development of spray-dried powder hand sanitiser with prolonged effectivity</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d < 10 µm), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against
E.
coli
and
S.
epidermidis
. The real-life performance was investigated with twelve volunteers performing various activities for up to 2 h. 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However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d < 10 µm), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against
E.
coli
and
S.
epidermidis
. The real-life performance was investigated with twelve volunteers performing various activities for up to 2 h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers’ fingers concerning the total amount of adhered and detached particles.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38413707</pmid><doi>10.1038/s41598-024-55503-w</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/326/22/1294 639/166/898 639/301/54/152 692/700 692/700/459 692/700/478/174 Alcohol use Antimicrobial agents Chitosan Chlorhexidine Controlled release COVID-19 Disinfectants E coli Ethanol Hands Health problems Humanities and Social Sciences Hygiene Irritation multidisciplinary Nanoparticles Pandemics Pathogens Personal hygiene Public health Sanitizers Science Science (multidisciplinary) Skin Topology |
| title | Development of spray-dried powder hand sanitiser with prolonged effectivity |
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