Circulating microRNA as diagnostic biomarkers for haematological cancers: a systematic review and meta-analysis

Recent studies have validated microRNAs (miRNAs) as a diagnostic biomarker for haematological cancers. This study aimed to estimate the overall diagnostic accuracy of circulating miRNAs in haematological malignancies. Multiple databases (Google Scholar, PubMed, EMBASE, Cochrane Library,) were search...

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Bibliographic Details
Published in:Cancer management and research 2019-05, Vol.11, p.4313-4326
Main Authors: Drokow, Emmanuel Kwateng, Sun, Kai, Ahmed, Hafiz Abdul Waqas, Akpabla, Gloria Selorm, Song, Juanjuan, Shi, Mingyue
Format: Article
Language:English
Subjects:
Analysis
Anopheles
Biological markers
Cancer
Cancer research
diagnostic biomarkers
haematological cancers
MicroRNA
miRNA
Original Research
sensitivity
Specificity
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Summary:Recent studies have validated microRNAs (miRNAs) as a diagnostic biomarker for haematological cancers. This study aimed to estimate the overall diagnostic accuracy of circulating miRNAs in haematological malignancies. Multiple databases (Google Scholar, PubMed, EMBASE, Cochrane Library,) were searched until 19 August 2017. The meta-analysis included 50 studies from 20 publications. The diagnostic accuracy was assessed by pooled specificity, sensitivity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and area under the curve area (AUC) by random effect model. We used QUADAS (Quality Assessment for diagnostic accuracy studies) to evaluate the quality of the included studies. To perform the meta-analysis, we used Meta-Disk 1.4, Revman 5.3 and Stata 12.0 software. High diagnostic accuracy was demonstrated, with a sensitivity of 0.81, a specificity of 0.85, a PLR of 5.28, an NLR of 0.22, a DOR of 30.39, and an AUC of 0.91. Subgroup analyses showed better outcomes for the African population, combined miRNAs and leukaemia patients compared with other subgroups. Our results indicated that circulating miRNAs especially combined miRNA can be used as a diagnostic marker in haematological cancers.
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S199126