Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?

Highlights • Perinatal transmission of hepatitis B virus (HBV) still occurs despite infant hepatitis B vaccination. • Maternal HBV viraemia is the main risk factor for perinatal transmission. • The hepatitis B surface antigen (HBsAg) level is a good viral load predictor in hepatitis B e antigen (HBe...

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Bibliographic Details
Published in:International journal of infectious diseases 2015-12, Vol.41 (C), p.83-89
Main Authors: Fujiko, Masita, Chalid, Maisuri T, Turyadi, Ie, Susan I, Maghfira, Syafri, Wahyuni, Ridha, Roni, Martono, Patellongi, Ilhamjaya, Massi, M. Nasrum, Muljono, David H
Format: Article
Language:English
Subjects:
Adult
Base Sequence
DNA, Viral - genetics
Female
Genotype
HBsAg level
HBV DNA level
HBV vertical transmission
Hepatitis B Antibodies - immunology
Hepatitis B e Antigens - genetics
Hepatitis B Surface Antigens - blood
Hepatitis B virus - genetics
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - virology
Humans
Indonesia - epidemiology
Infectious Disease
Infectious Disease Transmission, Vertical
Mother-to-child-transmission
Mutation
Pregnancy
Pregnancy Complications, Infectious - virology
Pregnant women
Prevalence
Promoter Regions, Genetic
Pulmonary/Respiratory
Real-Time Polymerase Chain Reaction
Serologic Tests
Viral Load
Viremia - immunology
Young Adult
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Summary:Highlights • Perinatal transmission of hepatitis B virus (HBV) still occurs despite infant hepatitis B vaccination. • Maternal HBV viraemia is the main risk factor for perinatal transmission. • The hepatitis B surface antigen (HBsAg) level is a good viral load predictor in hepatitis B e antigen (HBeAg)-positive pregnant women. • HBeAg-negative status could be due to HBV variants defective for HBeAg production. • HBV DNA quantification is not required for pregnant women with low HBsAg levels.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.11.002