The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral Infections

Sirtuins (SIRTs) are nicotinamide adenine dinucleotide-dependent histone deacetylases that incorporate complex functions in the mechanisms of cell physiology. Mammals have seven distinct members of the SIRT family (SIRT1-7), which play an important role in a well-maintained network of metabolic path...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-02, Vol.10 (2), p.460
Main Authors: Alqarni, Mohammed Hamed, Foudah, Ahmed Ibrahim, Muharram, Magdy Mohamed, Labrou, Nikolaos E
Format: Article
Language:English
Subjects:
Acetylation
Adenine
Amino acids
Animals
antiviral
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Apoptosis
Bibliographic data bases
Binding sites
Biosynthesis
Calories
Cell cycle
Cellular stress response
Circadian rhythm
Coronaviruses
COVID-19
Deoxyribonucleic acid
DNA
DNA repair
Drug Discovery
Enzymes
Fatty acids
Gene expression
Histones
Humans
infection
Inflammation
Mammals
Metabolic Networks and Pathways - drug effects
Metabolic pathways
Metabolism
Mitochondria
Models, Molecular
Molecular Targeted Therapy
NAD
NAD - metabolism
Proteins
Review
Severe acute respiratory syndrome coronavirus 2
SIRT1 protein
Sirtuins
Sirtuins - analysis
Sirtuins - metabolism
Transcription factors
Tumor necrosis factor-TNF
Virus Diseases - drug therapy
Virus Diseases - metabolism
Viruses - drug effects
Viruses - metabolism
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Summary:Sirtuins (SIRTs) are nicotinamide adenine dinucleotide-dependent histone deacetylases that incorporate complex functions in the mechanisms of cell physiology. Mammals have seven distinct members of the SIRT family (SIRT1-7), which play an important role in a well-maintained network of metabolic pathways that control and adapt the cell to the environment, energy availability and cellular stress. Until recently, very few studies investigated the role of SIRTs in modulating viral infection and progeny. Recent studies have demonstrated that SIRT1 and SIRT2 are promising antiviral targets because of their specific connection to numerous metabolic and regulatory processes affected during infection. In the present review, we summarize some of the recent progress in SIRTs biochemistry and their emerging function as antiviral targets. We also discuss the potential of natural polyphenol-based SIRT modulators to control their functional roles in several diseases including viral infections.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10020460