Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ : A Case Report

Several cases of pigmented mammary Paget's disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case o...

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Published in:Frontiers in medicine 2022-03, Vol.9, p.839954
Main Authors: Rao, Shijia, Wang, Alun, Liu, Wei, Yin, Hongling, Li, Ji, Tsang, Lemuel Shui-Lun, Wu, Yuhui, Shi, Wei
Format: Article
Language:English
Subjects:
dermatology
mammary Paget disease
Medicine
melanocytic proliferation
melanoma in situ
pathology
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Wang, Alun
Liu, Wei
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Wu, Yuhui
Shi, Wei
description Several cases of pigmented mammary Paget's disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease.
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subjects dermatology
mammary Paget disease
Medicine
melanocytic proliferation
melanoma in situ
pathology
title Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ : A Case Report
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