Ficus septica plant extracts for treating Dengue virus in vitro

Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the . DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, w...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2017-06, Vol.5, p.e3448-e3448, Article e3448
Main Authors: Huang, Nan-Chieh, Hung, Wan-Ting, Tsai, Wei-Lun, Lai, Feng-Yi, Lin, You-Sheng, Huang, Mei-Shu, Chen, Jih-Jung, Lin, Wei-Yu, Weng, Jing-Ru, Chang, Tsung-Hsien
Format: Article
Language:English
Subjects:
Aichi virus
Biotechnology
Care and treatment
Cell growth
Crude extract
Cytotoxicity
Dengue fever
Dengue virus
Disease
Drugs and Devices
Ficus septica
Flaviviridae
Hepatitis
Herbal medicine
Hospitals
Immunofluorescence
Infections
Leaves
Medicinal plants
Medicine
Pharmacy
Plant extracts
Plant viruses
RNA viruses
Severe acute respiratory syndrome
Virology
Viruses
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Summary:Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the . DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plants ; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem from Burm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelope , Aichi virus, was not inhibited by treatment with extracts. may be a candidate antiviral drug against an enveloped virus such as DENV.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.3448