Nonlinear and Robust Control Strategy Based on Chemotherapy to Minimize the HIV Concentration in Blood Plasma

A nonlinear PI-type control strategy is designed in order to minimize the HIV concentration in blood plasma, via medical drug injection, under the framework of bounded uncertain input disturbances. For control design it is considered a simplified mathematical model of the virus infection as a benchm...

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Bibliographic Details
Published in:Journal of control science and engineering 2016-01, Vol.2016 (2016), p.1-6
Main Authors: Femat, Ricardo, Lara-Cisneros, Gerardo, Gómez-Acata, Rigel Valentín, Aguilar-López, R.
Format: Article
Language:English
Subjects:
Blood plasma
Controllers
Disturbances
Drugs
HIV
Lentivirus
Mathematical models
Nonlinearity
Viruses
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Summary:A nonlinear PI-type control strategy is designed in order to minimize the HIV concentration in blood plasma, via medical drug injection, under the framework of bounded uncertain input disturbances. For control design it is considered a simplified mathematical model of the virus infection as a benchmark. The model is based on mass balances of healthy cells, infected cells, and the virus concentrations. The proposed controller contains a nonlinear feedback PI structure of bounded functions of the regulation error. The closed-loop stability of the system is analyzed via Lyapunov technique, in which robustness against system disturbances is demonstrated. Numerical experiments show a satisfactory performance of the proposed methodology as a HIV therapy, in which the virion particles and the infected CD4+T cells are minimized and, as an interesting result, the drug dosage can be suspended, thus avoiding drug resistance from the virus. Finally, the proposed controller is compared to a standard sliding-mode and hyperbolic tangent controllers showing better performance.
ISSN:1687-5249
1687-5257
DOI:10.1155/2016/6284574