Elevated Levels of IL-10 and G-CSF Associated with Asymptomatic Malaria in Pregnant Women

In sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually. Nearly 36% of healthy pregnant women receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana. We tested the hypothesis that asymptomatic HRP II posit...

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Bibliographic Details
Published in:Infectious Diseases in Obstetrics and Gynecology 2010, Vol.2010 (2010), p.31-37
Main Authors: Wilson, Nana O., Bythwood, Tameka, Solomon, Wesley, Jolly, Pauline, Yatich, Nelly, Jiang, Yi, Shuaib, Faisal, Adjei, Andrew A., Anderson, Winston, Stiles, Jonathan K.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - analysis
Care and treatment
Case Report
Case studies
Development and progression
Diagnosis
Female
Granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor - blood
Health aspects
Humans
Interleukin-10
Interleukin-10 - blood
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - diagnosis
Medical research
Parasites
Physiological aspects
Plasmodium falciparum
Pregnancy
Pregnancy Complications, Infectious - blood
Pregnant women
Risk factors
Womens health
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Summary:In sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually. Nearly 36% of healthy pregnant women receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana. We tested the hypothesis that asymptomatic HRP II positive pregnant women expressed a unique Th1 and Th2 phenotype that differs from healthy controls. Plasma from healthy (n=15) and asymptomatic (n=25) pregnant women were evaluated for 27 biomarkers (IL-1b, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL- 17, Eotaxin, bFGF-2, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1, MIP-1α, MIP-1β, PDGF-bb, RANTES, TNF, and VEGF) associated with Th1 and Th2 cytokine homeostasis. IL-10 and G-CSF levels were elevated in the asymptomatic group when compared with the healthy group (P=.031 and .041, resp.). The median ratios of IL-1β:5, IL-1β:10, IL-1β:G-CSF, IL-1β:Eotaxin, IL-12:G-CSF, IL-15:10, IL-17:G-CSF, IL-17:Eotaxin, TNF:IL-4, TNF:IL-5, and TNF:G-CSF were significantly different among the two groups. Thus, asymptomatic malaria carriage may be linked to circulating levels of IL-10 and G-CSF.
ISSN:1064-7449
1098-0997
DOI:10.1155/2010/317430