Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: A review article

Osteoarthritis is one of the most common degenerative conditions affecting knee joint. As our understanding in the disease pathogenesis is evolving, so do the treatment modalities. One of the postulated mechanisms suggests the production of inflammatory cytokines secondary to repeated micro trauma t...

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Bibliographic Details
Published in:Orthopedic Reviews 2019-09, Vol.11 (3), p.7747-7747
Main Authors: Baloch, Naveed, Hasan, Obada, Baig, Zain, Abdullah, Umme-e-Hani, Atif, Mohammad, Ohuchi, Hiroshi
Format: Article
Language:English
Subjects:
Arthritis
Cartilage
Knee
knee osteoarthritis
Osteoarthritis
Plasma
Platelet-rich plasma
Review
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Summary:Osteoarthritis is one of the most common degenerative conditions affecting knee joint. As our understanding in the disease pathogenesis is evolving, so do the treatment modalities. One of the postulated mechanisms suggests the production of inflammatory cytokines secondary to repeated micro trauma than in turn lead to cartilage damage overtime. Cartilage being avascular structure has limited potential for repair. Based on this, recent studies have been focusing on stimulating cartilage-healing process by growth factors. This is where platelet-rich plasma comes in to light. Literature is showing promising results of platelet-rich plasma in treating knee osteoarthritis. In this review we have discussed the preparation, composition, classification, uses of platelet-rich plasma as well as evidence for its efficacy and complications.
ISSN:2035-8237
2035-8164
DOI:10.4081/or.2019.7747