Aberrant Alternative Splicing Is Another Hallmark of Cancer

The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases...

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Bibliographic Details
Published in:International Journal of Cell Biology 2013, Vol.2013 (2013), p.216-221
Main Author: Ladomery, Michael
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Cancer
Eukaryotes
Gene expression
Genetic engineering
Genetic research
Kinases
Metastasis
Oncology, Experimental
Proteins
Review
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Summary:The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases in cancer changes the alternative splicing of critically important pre-mRNAs. Aberrant alternative splicing should be added to the growing list of cancer hallmarks.
ISSN:1687-8876
1687-8884
DOI:10.1155/2013/463786