Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in periodontitis patients: a randomized clinical trial

Objectives This study aimed to assess the effects of omega-3 fatty acid supplementation as an adjunct to non-surgical periodontal therapy in patients with periodontitis. Materials and methods This randomized clinical trial was conducted on 30 patients with periodontitis. All patients received standa...

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Bibliographic Details
Published in:BMC oral health 2022-11, Vol.22 (1), p.1-521, Article 521
Main Authors: Maybodi, Fahimeh Rashidi, Fakhari, Mahsa, Tavakoli, Fatemeh
Format: Article
Language:English
Subjects:
Antibiotics
Biofilms
Care and treatment
Clinical trials
Dentistry
Diabetes
Dietary supplements
Disease
Docosahexaenoic acid
Eicosapentaenoic acid
Fatty acids
Fatty acids, Omega-3
Fish oils
Gels
Gene expression
Graduate students
Gum disease
Inflammation
Informed consent
Intervention
Methods
Nutrition research
Omega-3 fatty acids
Oral hygiene
Periodontal Diseases
Periodontics
Periodontitis
Smoking
Supplements
Testing
Therapeutics, Dental
Triglycerides
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Summary:Objectives This study aimed to assess the effects of omega-3 fatty acid supplementation as an adjunct to non-surgical periodontal therapy in patients with periodontitis. Materials and methods This randomized clinical trial was conducted on 30 patients with periodontitis. All patients received standard non-surgical periodontal therapy, and were randomly divided into two groups of intervention and control by a table of random numbers (n = 15). The intervention group consumed 1000 mg natural fish oil soft-gels daily (300 mg Omega-3 marine triglycerides, 180 mg Eicosapentaenoic acid and 120 mg Docosahexaenoic acid) while the control group used soft-gels contained only some soybean oil for 3 months. Clinical attachment loss (CAL), probing depth (PD), and bleeding index (BI) were recorded at baseline (before the intervention) and after 3 months. The two groups were compared regarding the clinical parameters by t-test (alpha = 0.05). Results All three clinical parameters decreased in both groups at 3 months compared with baseline (P = 0.001). The improvement in PD and CAL in the intervention group was significantly greater than that in the control group (P = 0.001); however, the difference in BI was not significant between the two groups (P = 0.283). Conclusion Omega-3 supplementation as an adjunct to non-surgical periodontal therapy significantly improved the clinical parameters in periodontitis patients compared to soybean oil supplements. Keywords: Fatty acids, Omega-3, Periodontal Diseases, Periodontitis
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-022-02569-5