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Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutriti...

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Published in:Scientific reports 2019-10, Vol.9 (1), p.14090-10, Article 14090
Main Authors: Oh, Na-Kyung, Song, Yun-Mi, Kim, Shin-Hye, Park, Mi Jung
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description Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutrition Examination Survey from 2007 to 2015, from 37,889 individuals (aged 12–59 years). In adolescents, total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels had profound associations with height in both boys and girls, while high density lipoprotein-cholesterol (HDL-C) levels had an inverse association with height only in boys. Height was inversely associated with TC, triglycerides (TG), and LDL-C concentrations in men and women and positively correlated with HDL-C concentration in women. In boys, the odds ratios (ORs) for hypercholesterolemia, hypertriglyceridemia, hyper-LDL-cholesterolemia were higher for shorter subjects (ORs = 2.38~7.01), while only the OR of hyper-LDL-cholesterolemia was significantly higher in girls with short stature (OR = 3.12). In adults, the ORs for hypercholesterolemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were significantly higher in short subjects than in tall subjects after controlling for covariates (ORs = 1.50~2.61). Also, short men showed significantly higher ORs for hypertriglyceridemia (OR = 1.85) than tall men. Short stature was significantly associated with adverse lipid profiles in both adolescents and adults.
doi_str_mv 10.1038/s41598-019-50524-2
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subjects 692/163/2743/1530
692/163/2743/2099
Adolescent
Adolescents
Adult
Age Factors
Body Height
Cardiovascular diseases
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Dyslipidemia
Dyslipidemias - etiology
Female
Growth Disorders - blood
Growth Disorders - complications
High density lipoprotein
Humanities and Social Sciences
Humans
Hypercholesterolemia
Hypertriglyceridemia
Low density lipoprotein
Male
Metabolic disorders
multidisciplinary
Nutrition Surveys
Odds Ratio
Republic of Korea
Risk Factors
Science
Science (multidisciplinary)
Sex Factors
Teenagers
Triglycerides
title Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
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