Genetic relationships among serogroup B: serotype 4 Neisseria meningitidis strains

We compared the results obtained by serotyping of PorB epitopes using an expanded panel of monoclonal antibodies (mAb) including mAb 7 and mAb 10, with results obtained by RFLP of rRNA genes (ribotyping). The purpose of this study was to assess the correlation between phenotypic- and genotypic- meth...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 2001-06, Vol.43 (3), p.119-124
Main Authors: Lemos, A P, Sacchi, C T, Paiva, M V, Yara, T I, Melles, C E, Mayer, L W
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane Proteins - genetics
Genetic Variation
Humans
Immunoglobulin Variable Region - genetics
Neisseria meningitidis
Neisseria meningitidis - classification
Neisseria meningitidis - genetics
Porins
Ribotyping
Serogroup B
Serotype 4
Serotyping
Strain differentiation
TROPICAL MEDICINE
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Summary:We compared the results obtained by serotyping of PorB epitopes using an expanded panel of monoclonal antibodies (mAb) including mAb 7 and mAb 10, with results obtained by RFLP of rRNA genes (ribotyping). The purpose of this study was to assess the correlation between phenotypic- and genotypic- methods for typing N. meningitidis. The ribotypes obtained using ClaI or EcoRV endonucleases grouped the strains in seven and two different patterns, respectively. This additional characterization of PorB epitopes improved the correlation between these two methods of typing N. meningitidis.
ISSN:0036-4665
1678-9946
0036-4665
1678-9946
DOI:10.1590/S0036-46652001000300001