Hyaluronic Acid in Bone Regeneration: Systematic Review and Meta-Analysis

The aim of this systematic review and meta-analysis was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when hyaluronic acid (HA) was added and mixed with graft materials in bone regeneration. This review was registered at the International Pro...

Full description

Saved in:
Bibliographic Details
Published in:Dentistry journal 2024-08, Vol.12 (8), p.263
Main Authors: Lorenzi, Claudia, Leggeri, Andrea, Cammarota, Ilaria, Carosi, Paolo, Mazzetti, Vincenzo, Arcuri, Claudio
Format: Article
Language:English
Subjects:
Bias
Biomedical materials
Blood clots
Bone grafts
Bone growth
bone regeneration
bone substitutes
Clinical trials
Grafting
Grafts
Grain size
Hyaluronic acid
Mediation
Meta-analysis
Mineralization
Neovascularization
Osteogenesis
Qualitative analysis
Regeneration
Regeneration (physiology)
Reviews
Skin & tissue grafts
Statistical analysis
Substitute bone
Surgery
Systematic Review
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this systematic review and meta-analysis was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when hyaluronic acid (HA) was added and mixed with graft materials in bone regeneration. This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) of the National Institute of Health Research (registration number CRD42024530030). Electronic research was performed, and involved studies published up to 29 February 2024 using a specific word combination. The primary outcome was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when HA was added and mixed with graft materials in bone regeneration. The search resulted in 138 potential studies. Meta-analyses were performed using the fixed and random effects model to identify significant changes in new bone formation and in the remaining graft particles. After screening procedures, only three randomized controlled trials fulfilled the inclusion criteria and were selected for qualitative and quantitative analysis. The effect size of HA in the new bone formation was not statistically significant at 95% CI (Z = 1.734, -value = 0.083, 95 % CI -,399; 6516). The effect size of HA in the remaining graft particles was not statistically significant at 95% CI (Z = -1.042, -value = 0.297, CI -,835; 255). Within the limitations of the present systematic review and meta-analysis, the addition of HA to bone graft did not result in significant changes in bone regeneration procedures in terms of new bone formation and residues, even if the included studies showed encouraging and promising results.
ISSN:2304-6767
2304-6767
DOI:10.3390/dj12080263