Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer

We aimed to assess resistin gene polymorphisms, namely 420C > G and 62G > A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus,...

Full description

Saved in:
Bibliographic Details
Published in:Taiwanese journal of obstetrics & gynecology 2019-01, Vol.58 (1), p.164-167
Main Authors: Ozgor, Bahar Yuksel, Iyibozkurt, Cem, Bastu, Ercan, Berkman, Sinan, Yalcın, Onay, Cakmakoglu, Bedia, Saygılı, Halil
Format: Article
Language:English
Subjects:
Endometrial cancer
Gene polymorphism
Resistin
SNP
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to assess resistin gene polymorphisms, namely 420C > G and 62G > A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus, hypertension and history of any other cancer were excluded. To identify the importance of nucleotide polymorphism including 420C > G and 62G > A in the resistin gene, 94 healthy volunteers were included as the control group. Among the Resistin 420 gene polymorphism profiles, 420 GC (47.9%) was the most common gene polymorphism in the EC group. Also, the polymorphism of 420 CC (57.7%, p: 0.002) lead the list in the control group followed by the 420GC (37.5%) polymorphism. Resistin 62 gene polymorphism analysis demonstrated that the 62GC polymorphism was significantly more common in the EC group (p 
ISSN:1028-4559
DOI:10.1016/j.tjog.2018.11.030