Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer

We aimed to assess resistin gene polymorphisms, namely 420C > G and 62G > A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus,...

Full description

Saved in:
Bibliographic Details
Published in:Taiwanese journal of obstetrics & gynecology 2019-01, Vol.58 (1), p.164-167
Main Authors: Ozgor, Bahar Yuksel, Iyibozkurt, Cem, Bastu, Ercan, Berkman, Sinan, Yalcın, Onay, Cakmakoglu, Bedia, Saygılı, Halil
Format: Article
Language:English
Subjects:
Endometrial cancer
Gene polymorphism
Resistin
SNP
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53
cites cdi_FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53
container_end_page 167
container_issue 1
container_start_page 164
container_title Taiwanese journal of obstetrics & gynecology
container_volume 58
creator Ozgor, Bahar Yuksel
Iyibozkurt, Cem
Bastu, Ercan
Berkman, Sinan
Yalcın, Onay
Cakmakoglu, Bedia
Saygılı, Halil
description We aimed to assess resistin gene polymorphisms, namely 420C > G and 62G > A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus, hypertension and history of any other cancer were excluded. To identify the importance of nucleotide polymorphism including 420C > G and 62G > A in the resistin gene, 94 healthy volunteers were included as the control group. Among the Resistin 420 gene polymorphism profiles, 420 GC (47.9%) was the most common gene polymorphism in the EC group. Also, the polymorphism of 420 CC (57.7%, p: 0.002) lead the list in the control group followed by the 420GC (37.5%) polymorphism. Resistin 62 gene polymorphism analysis demonstrated that the 62GC polymorphism was significantly more common in the EC group (p 
doi_str_mv 10.1016/j.tjog.2018.11.030
format article
fullrecord <record><control><sourceid>elsevier_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_ac0ac41e470a46c8a8496f4f7ea7c21e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1028455918303073</els_id><doaj_id>oai_doaj_org_article_ac0ac41e470a46c8a8496f4f7ea7c21e</doaj_id><sourcerecordid>S1028455918303073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhvegYK3-AU_5A10n2ewXeJHiR6HgpScvYTY7abN0NyUJlf57UysePQ28w_My82TZA4ecA68ehzwObpsL4E3OeQ4FXGUzDqJZyLJsb7LbEAYAWQPALPtcTUcK0W4xWjcxZ5inYFMwMSmA4dSzSrAtTcQObn8anT_sbBhZ2h8SQlMM7MvGHaOpdyNFb3HPNE6a_F12bXAf6P53zrPN68tm-b5Yf7ytls_rhZZFEReFMRxINLwqQVYSig6kBKFlL4TpKlmU1DQGSbRN1xotWtNhoZGorQV1ZTHPVpfa3uGgDt6O6E_KoVU_gfNbhT5avSeFGlBLTul3lJVusJFtZaSpCWstOKUucenS3oXgyfz1cVBnuWpQZ7nqLFdxrpLcBD1dIEpPHi15FXQSo6m3nnRMZ9j_8G_ST4W6</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Ozgor, Bahar Yuksel ; Iyibozkurt, Cem ; Bastu, Ercan ; Berkman, Sinan ; Yalcın, Onay ; Cakmakoglu, Bedia ; Saygılı, Halil</creator><creatorcontrib>Ozgor, Bahar Yuksel ; Iyibozkurt, Cem ; Bastu, Ercan ; Berkman, Sinan ; Yalcın, Onay ; Cakmakoglu, Bedia ; Saygılı, Halil</creatorcontrib><description>We aimed to assess resistin gene polymorphisms, namely 420C &gt; G and 62G &gt; A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus, hypertension and history of any other cancer were excluded. To identify the importance of nucleotide polymorphism including 420C &gt; G and 62G &gt; A in the resistin gene, 94 healthy volunteers were included as the control group. Among the Resistin 420 gene polymorphism profiles, 420 GC (47.9%) was the most common gene polymorphism in the EC group. Also, the polymorphism of 420 CC (57.7%, p: 0.002) lead the list in the control group followed by the 420GC (37.5%) polymorphism. Resistin 62 gene polymorphism analysis demonstrated that the 62GC polymorphism was significantly more common in the EC group (p &lt; 0.01), while 62 AG (52.9%) was observed most frequently in the control group bringing about a reduction in the risk of EC (p &lt; 0.01, Odds Ratio:0.37). Additionally, the alleles of 420G+ and 62A + were significantly more common in the EC group and the control group, respectively (p:0.02 and p&lt;:0.01). Multivariate regression analysis revealed that the presence of 420G + allele increased the EC risk 1.99 fold while the presence of 62A + allele was shown to decrease the risk of EC (p&lt;:0.01 Odds Ratio:0.038). Our study for the first time had demonstrated that Resistin 420G &gt; C and 62G &gt; A gene polymorphisms play a role in EC development.</description><identifier>ISSN: 1028-4559</identifier><identifier>DOI: 10.1016/j.tjog.2018.11.030</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Endometrial cancer ; Gene polymorphism ; Resistin ; SNP</subject><ispartof>Taiwanese journal of obstetrics &amp; gynecology, 2019-01, Vol.58 (1), p.164-167</ispartof><rights>2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53</citedby><cites>FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ozgor, Bahar Yuksel</creatorcontrib><creatorcontrib>Iyibozkurt, Cem</creatorcontrib><creatorcontrib>Bastu, Ercan</creatorcontrib><creatorcontrib>Berkman, Sinan</creatorcontrib><creatorcontrib>Yalcın, Onay</creatorcontrib><creatorcontrib>Cakmakoglu, Bedia</creatorcontrib><creatorcontrib>Saygılı, Halil</creatorcontrib><title>Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer</title><title>Taiwanese journal of obstetrics &amp; gynecology</title><description>We aimed to assess resistin gene polymorphisms, namely 420C &gt; G and 62G &gt; A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus, hypertension and history of any other cancer were excluded. To identify the importance of nucleotide polymorphism including 420C &gt; G and 62G &gt; A in the resistin gene, 94 healthy volunteers were included as the control group. Among the Resistin 420 gene polymorphism profiles, 420 GC (47.9%) was the most common gene polymorphism in the EC group. Also, the polymorphism of 420 CC (57.7%, p: 0.002) lead the list in the control group followed by the 420GC (37.5%) polymorphism. Resistin 62 gene polymorphism analysis demonstrated that the 62GC polymorphism was significantly more common in the EC group (p &lt; 0.01), while 62 AG (52.9%) was observed most frequently in the control group bringing about a reduction in the risk of EC (p &lt; 0.01, Odds Ratio:0.37). Additionally, the alleles of 420G+ and 62A + were significantly more common in the EC group and the control group, respectively (p:0.02 and p&lt;:0.01). Multivariate regression analysis revealed that the presence of 420G + allele increased the EC risk 1.99 fold while the presence of 62A + allele was shown to decrease the risk of EC (p&lt;:0.01 Odds Ratio:0.038). Our study for the first time had demonstrated that Resistin 420G &gt; C and 62G &gt; A gene polymorphisms play a role in EC development.</description><subject>Endometrial cancer</subject><subject>Gene polymorphism</subject><subject>Resistin</subject><subject>SNP</subject><issn>1028-4559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kE1LAzEQhvegYK3-AU_5A10n2ewXeJHiR6HgpScvYTY7abN0NyUJlf57UysePQ28w_My82TZA4ecA68ehzwObpsL4E3OeQ4FXGUzDqJZyLJsb7LbEAYAWQPALPtcTUcK0W4xWjcxZ5inYFMwMSmA4dSzSrAtTcQObn8anT_sbBhZ2h8SQlMM7MvGHaOpdyNFb3HPNE6a_F12bXAf6P53zrPN68tm-b5Yf7ytls_rhZZFEReFMRxINLwqQVYSig6kBKFlL4TpKlmU1DQGSbRN1xotWtNhoZGorQV1ZTHPVpfa3uGgDt6O6E_KoVU_gfNbhT5avSeFGlBLTul3lJVusJFtZaSpCWstOKUucenS3oXgyfz1cVBnuWpQZ7nqLFdxrpLcBD1dIEpPHi15FXQSo6m3nnRMZ9j_8G_ST4W6</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Ozgor, Bahar Yuksel</creator><creator>Iyibozkurt, Cem</creator><creator>Bastu, Ercan</creator><creator>Berkman, Sinan</creator><creator>Yalcın, Onay</creator><creator>Cakmakoglu, Bedia</creator><creator>Saygılı, Halil</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>201901</creationdate><title>Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer</title><author>Ozgor, Bahar Yuksel ; Iyibozkurt, Cem ; Bastu, Ercan ; Berkman, Sinan ; Yalcın, Onay ; Cakmakoglu, Bedia ; Saygılı, Halil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Endometrial cancer</topic><topic>Gene polymorphism</topic><topic>Resistin</topic><topic>SNP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozgor, Bahar Yuksel</creatorcontrib><creatorcontrib>Iyibozkurt, Cem</creatorcontrib><creatorcontrib>Bastu, Ercan</creatorcontrib><creatorcontrib>Berkman, Sinan</creatorcontrib><creatorcontrib>Yalcın, Onay</creatorcontrib><creatorcontrib>Cakmakoglu, Bedia</creatorcontrib><creatorcontrib>Saygılı, Halil</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Taiwanese journal of obstetrics &amp; gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozgor, Bahar Yuksel</au><au>Iyibozkurt, Cem</au><au>Bastu, Ercan</au><au>Berkman, Sinan</au><au>Yalcın, Onay</au><au>Cakmakoglu, Bedia</au><au>Saygılı, Halil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer</atitle><jtitle>Taiwanese journal of obstetrics &amp; gynecology</jtitle><date>2019-01</date><risdate>2019</risdate><volume>58</volume><issue>1</issue><spage>164</spage><epage>167</epage><pages>164-167</pages><issn>1028-4559</issn><abstract>We aimed to assess resistin gene polymorphisms, namely 420C &gt; G and 62G &gt; A and their effect on the risk of endometrial cancer (EC). Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus, hypertension and history of any other cancer were excluded. To identify the importance of nucleotide polymorphism including 420C &gt; G and 62G &gt; A in the resistin gene, 94 healthy volunteers were included as the control group. Among the Resistin 420 gene polymorphism profiles, 420 GC (47.9%) was the most common gene polymorphism in the EC group. Also, the polymorphism of 420 CC (57.7%, p: 0.002) lead the list in the control group followed by the 420GC (37.5%) polymorphism. Resistin 62 gene polymorphism analysis demonstrated that the 62GC polymorphism was significantly more common in the EC group (p &lt; 0.01), while 62 AG (52.9%) was observed most frequently in the control group bringing about a reduction in the risk of EC (p &lt; 0.01, Odds Ratio:0.37). Additionally, the alleles of 420G+ and 62A + were significantly more common in the EC group and the control group, respectively (p:0.02 and p&lt;:0.01). Multivariate regression analysis revealed that the presence of 420G + allele increased the EC risk 1.99 fold while the presence of 62A + allele was shown to decrease the risk of EC (p&lt;:0.01 Odds Ratio:0.038). Our study for the first time had demonstrated that Resistin 420G &gt; C and 62G &gt; A gene polymorphisms play a role in EC development.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.tjog.2018.11.030</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1028-4559
ispartof Taiwanese journal of obstetrics & gynecology, 2019-01, Vol.58 (1), p.164-167
issn 1028-4559
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_ac0ac41e470a46c8a8496f4f7ea7c21e
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects Endometrial cancer
Gene polymorphism
Resistin
SNP
title Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T13%3A06%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20resistin%20420%20and%2062%20gene%20polymorphism%20in%20patients%20with%20endometrial%20cancer&rft.jtitle=Taiwanese%20journal%20of%20obstetrics%20&%20gynecology&rft.au=Ozgor,%20Bahar%20Yuksel&rft.date=2019-01&rft.volume=58&rft.issue=1&rft.spage=164&rft.epage=167&rft.pages=164-167&rft.issn=1028-4559&rft_id=info:doi/10.1016/j.tjog.2018.11.030&rft_dat=%3Celsevier_doaj_%3ES1028455918303073%3C/elsevier_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c433t-3ff10e28165046403b04402c4d22fb6435e88fae298b9fc29fba3caee972eb53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true