Prognostic nomograms for predicting overall and cancer-specific survival of high-grade osteosarcoma patients

The present study aimed to develop nomograms estimating survival for patients with high-grade osteosarcoma. 1990 patients with high-grade osteosarcoma between 1994 and 2013 were retrospectively retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Data from 12 cancer regist...

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Bibliographic Details
Published in:Journal of bone oncology 2018-11, Vol.13, p.106-113
Main Authors: Song, Kehan, Song, Jian, Chen, Feiyan, Lin, Kaiyuan, Ma, Xiaosheng, Jiang, Jianyuan
Format: Article
Language:English
Subjects:
Nomogram
Osteosarcoma
Prognostic factor
Survival
Validation
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Summary:The present study aimed to develop nomograms estimating survival for patients with high-grade osteosarcoma. 1990 patients with high-grade osteosarcoma between 1994 and 2013 were retrospectively retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Data from 12 cancer registries (n = 1460) were used to conduct multivariate Cox analysis to identify independent prognostic factors. Nomograms which estimate 3- and 5-year overall survival (OS) and cancer-specific survival (CSS) were constructed. The nomograms were internally validated for calibration and were also externally validated with an independent patient cohort from 1 cancer registry (n = 530). Age, primary site, tumor size, use of surgery, and extent of disease were found to be independently associated with OS and CSS (p 
ISSN:2212-1374
2212-1366
2212-1374
DOI:10.1016/j.jbo.2018.09.012