India ink induces apoptosis in the yellow clam Mesodesma mactroides (Deshayes, 1854). Optical and ultrastructural study

This paper reports on the acute inflammatory and cellular process in the yellow clam, Mesodesma mactroides, induced by injection of India ink into the muscular foot. Histological observations with optical and electronic microscopy were made at 24 and 48 h after injection. The induced cellular inflam...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências 2015-12, Vol.87 (4), p.1981-1989
Main Authors: Carvalho, Yuri B M, Jethro, Juan, Poersch, Luis H, Romano, Luis A
Format: Article
Language:English
Subjects:
Animals
apoptose
Apoptosis - drug effects
Bivalvia - drug effects
Bivalvia - ultrastructure
Carbon - toxicity
estresse do retículo endoplasmático
Inflammation - chemically induced
Mesodesma mactroides
Microscopy, Electron
MULTIDISCIPLINARY SCIENCES
Necrosis - chemically induced
processo inflamatório
Time Factors
tinta nanquim
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Summary:This paper reports on the acute inflammatory and cellular process in the yellow clam, Mesodesma mactroides, induced by injection of India ink into the muscular foot. Histological observations with optical and electronic microscopy were made at 24 and 48 h after injection. The induced cellular inflammatory response consisted of a general hemocyte infiltration without necrosis and apoptotic activity. Migration of ink-laden phagocytes across the intestinal epithelium was recorded. It appeared that the yellow clam "excreted" ink particles through the gill and kidney. The positive staining for apoptosis was observed in the digestive gland. Electronic microscopy revealed ultrastructural changes of endoplasmic reticulum stress and apoptotic bodies in the digestive gland. The mechanism by which the India ink particles induce apoptosis remains unknown, but might possibly be associated with the endoplasmic reticulum stress. This work has highlighted features that require further discussion in the restricted field the inflammatory responses of mollusks.
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765201520140600