The relationship between serum vitamin D, testosterone, and oxidative stress levels in women with sexual dysfunction: A case-controlled study

Female sexual dysfunction (FSD) is highly prevalent and can result from hypovitaminosis D. Besides the role of vitamin D in normal bone development, studies showed it could reduce oxidative stress and lipid peroxidation. This prospective study aims to evaluate the relationship between serum vitamin...

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Bibliographic Details
Published in:Taiwanese journal of obstetrics & gynecology 2024-09, Vol.63 (5), p.673-678
Main Authors: Rafati, Mohammadreza, Bazrafshan, Elahe, Shaki, Fatemeh, Ghalini-Moghaddam, Tahereh, Moghimi, Minoo
Format: Article
Language:English
Subjects:
Female sexual dysfunction
FSFI
Oxidative stress
Vitamin D
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Summary:Female sexual dysfunction (FSD) is highly prevalent and can result from hypovitaminosis D. Besides the role of vitamin D in normal bone development, studies showed it could reduce oxidative stress and lipid peroxidation. This prospective study aims to evaluate the relationship between serum vitamin D, testosterone, and oxidative stress levels in women with FSD. In this cross-sectional study, a total of 40 women with FSD (age range: 18–45 years) were randomly assigned into two groups of intervention and control. In the intervention group, patients received vitamin D 300,000 IU intramuscularly (IM) and then 50,000 IU orally once a week for four weeks. We measured the serum vitamin D, testosterone, and oxidative stress levels, as well as the Female Sexual Function Index (FSFI) at baseline and monthly for three months. Serum testosterone levels significantly increased in the intervention group at the end of the third month (P = 0.014). Also, FSFI scores significantly improved (P 
ISSN:1028-4559
DOI:10.1016/j.tjog.2024.06.004