Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection : Implications for HIV Vaccine Development

The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune...

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Bibliographic Details
Published in:Advances in virology 2012-01, Vol.2012 (2012), p.1-8
Main Authors: Isitman, Gamze, Stratov, Ivan, Kent, Stephen J.
Format: Article
Language:English
Subjects:
Review
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Summary:The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune escape through both direct Killer-immunoglobulin-like receptor (KIR)-mediated killing as well as through facilitating antibody-dependent cellular cytotoxicity (ADCC). These newer finding suggest NK cells and ADCC responses apply significant pressure to the virus. There is an opportunity to harness these immune responses in the design of more effective HIV vaccines.
ISSN:1687-8639
1687-8647
DOI:10.1155/2012/637208