Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring

We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring...

Full description

Saved in:
Bibliographic Details
Published in:Beilstein journal of organic chemistry 2010-07, Vol.6 (1), p.71
Main Authors: Kodimuthali, Arumugam, Prasunamba, Padala Lakshmi, Pal, Manojit
Format: Article
Language:English
Subjects:
Alogliptin
Chemistry
cyclopropyl ring
DPP-4
piperidine
Preliminary Communication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring prior to assembling the piperidine ring.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.6.71