Development of the early-life gut microbiome and associations with eczema in a prospective Chinese cohort

Eczema is a major allergic disease in children, which is particularly prevalent in Chinese children during their first year of life. In this study, we showed that alterations in the infant gut microbiota precede the development of eczema in a prospective Chinese cohort. In particular, we discovered...

Full description

Saved in:
Bibliographic Details
Published in:mSystems 2023-10, Vol.8 (5), p.e0052123-e0052123
Main Authors: Cheung, Man Kit, Leung, Ting Fan, Tam, Wing Hung, Leung, Agnes S Y, Chan, Oi Man, Ng, Rita W Y, Yau, Jennifer W K, Yuen, Lai-Yuk, Tong, Sylvia L Y, Ho, Wendy C S, Yeung, Apple C M, Chen, Zigui, Chan, Paul K S
Format: Article
Language:English
Subjects:
atopic dermatitis
cesarean section
Child
China - epidemiology
Clostridium
Clostridium sensu stricto 1
early childhood
Eczema - epidemiology
Feces
Female
Gastrointestinal Microbiome
gut microbiota
Humans
infancy
Infant
Pregnancy
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eczema is a major allergic disease in children, which is particularly prevalent in Chinese children during their first year of life. In this study, we showed that alterations in the infant gut microbiota precede the development of eczema in a prospective Chinese cohort. In particular, we discovered enrichments of the genera and in the cases at 3 and 1 month of age, respectively, which may represent potential targets for intervention to prevent eczema. Besides, we identified a depletion of from 1 to 6 months of age and an enrichment of at 3 months in the eczema cases, patterns also observed in C-section-born infants within the same time frames, providing first evidence to support a role of the gut microbiota in previously reported associations between C-section and increased risk of eczema in infancy.
ISSN:2379-5077
2379-5077
DOI:10.1128/msystems.00521-23