IGF1 for the diagnosis of growth hormone deficiency in children and adolescents: a reappraisal

A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two child...

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Bibliographic Details
Published in:Endocrine Connections 2020-11, Vol.9 (11), p.1095-1102
Main Authors: Ibba, Anastasia, Corrias, Francesca, Guzzetti, Chiara, Casula, Letizia, Salerno, Mariacarolina, di Iorgi, Natascia, Tornese, Gianluca, Patti, Giuseppa, Radetti, Giorgio, Maghnie, Mohamad, Cappa, Marco, Loche, Sandro
Format: Article
Language:English
Subjects:
adolescents
children
growth hormone deficiency
insulin-like growth factor 1
short stature
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Summary:A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two children and adolescents with GHD ((63 organic/genetic (OGHD), 79 idiopathic (IGHD)) and 658 short non-GHD children (median age 10.4 years) were included in the analysis. The two groups were subdivided according to age (G1
ISSN:2049-3614
2049-3614
DOI:10.1530/EC-20-0347