Yeast hydrolysate attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage in weaned piglets

• Published in: Journal of animal science and biotechnology 2023-03, Vol.14 (1), p.44-44, Article 44
• Main Authors: Fu, Runqi, Liang, Chan, Chen, Daiwen, Tian, Gang, Zheng, Ping, He, Jun, Yu, Jie, Mao, Xiangbing, Luo, Yuheng, Luo, Junqiu, Yu, Bing
• Format: Article
• Language: English
• Subjects: Abundance; Acids; Adrenocorticotropic hormone; Animals; Antigens; Attenuation; Biological effects; Body weight; Cortisol; Cytokines; Damage; Diamines; Diet; Down-regulation; Feed additives; Feeds; Haptoglobin; Health promotion; Hogs; Hydrocortisone; Hydrolysates; IL-1β; Inflammation; Inflammatory response; Interleukins; Intestinal barrier; Intestine; Lipopolysaccharide; Lipopolysaccharides; Morphology; mRNA; Mucosa; NF-κB protein; Nutrients; Permeability; Phosphors; Physical growth; Physiology; Piglets; Proteins; Risk factors; Signal transduction; Small intestine; Soybeans; Swine; TLR4 protein; Toll-like receptors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Villus; Yeast; Yeast hydrolysate; Yeasts; Zonula occludens-1 protein
• ISSN: 1674-9782; 2049-1891; 2049-1891
• DOI: 10.1186/s40104-023-00835-2

Intestinal inflammation is the main risk factor causing intestinal barrier dysfunction and lipopolysaccharide (LPS) can trigger inflammatory responses in various eukaryotic species. Yeast hydrolysate (YH) possesses multi-biological effects and is received remarkable attention as a functional ingredient for improving growth performance and promoting health in animals. However, there is still inconclusive on the protective effects of dietary YH supplementation on intestinal barrier of piglets. This study was conducted to investigate the attenuate effects of YH supplementation on inflammatory responses and intestinal barrier injury in piglets challenged with LPS. Twenty-four piglets (with an average body weight of 7.42 ± 0.34 kg) weaned at 21 days of age were randomly assigned to one of two dietary treatments (12 replications with one pig per pen): a basal diet or a basal diet containing YH (5 g/kg). On the 22 d, 6 piglets in each treatment were intraperitoneally injected with LPS at 150 μg/kg BW, and the others were injected with the same amount of sterile normal saline. Four hours later, blood samples of each piglet were collected and then piglets were euthanized. Dietary YH supplementation increased average daily feed intake and average daily gain (P