Understanding the nose–brain axis and its role in related diseases: A conceptual review

The nose–brain axis (NBA), a critical component of the body–brain axis, not only serves as a drug transport route for the treatment of brain diseases but also mediates changes such as neuroimmune disorders, which may be an important mechanism in the occurrence and development of some nasal or brain...

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Published in:Neurobiology of disease 2024-11, Vol.202, p.106690, Article 106690
Main Authors: Mou, Ya-Kui, Song, Xiao-Yu, Wang, Han-Rui, Wang, Yao, Liu, Wan-Chen, Yang, Ting, Zhang, Ming-Jun, Hu, Yue, Ren, Chao, Song, Xi-Cheng
Format: Article
Language:English
Subjects:
Allergic rhinitis
Animals
Brain - metabolism
Brain Diseases - metabolism
Brain Diseases - physiopathology
Humans
Microglia
Neuroimmune
Nose
Nose Diseases
Nose–brain axis
Olfactory bulb
Parkinson's disease
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container_start_page 106690
container_title Neurobiology of disease
container_volume 202
creator Mou, Ya-Kui
Song, Xiao-Yu
Wang, Han-Rui
Wang, Yao
Liu, Wan-Chen
Yang, Ting
Zhang, Ming-Jun
Hu, Yue
Ren, Chao
Song, Xi-Cheng
description The nose–brain axis (NBA), a critical component of the body–brain axis, not only serves as a drug transport route for the treatment of brain diseases but also mediates changes such as neuroimmune disorders, which may be an important mechanism in the occurrence and development of some nasal or brain diseases. Despite its importance, there are substantial gaps that remain in our understanding of the characteristics of NBA-mediated diseases and of the cellular and molecular mechanisms underlying the bidirectional NBA crosstalk. These gaps have limited the translational application of NBA-related research findings to some extent. Therefore, this review aims to address the conceptual framework of NBA and highlight its values in representative diseases by combining existing literature with new research results from our group. We hope that this paper will provide a basis for further in-depth research in this field, and facilitate the clinical translation of NBA.
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subjects Allergic rhinitis
Animals
Brain - metabolism
Brain Diseases - metabolism
Brain Diseases - physiopathology
Humans
Microglia
Neuroimmune
Nose
Nose Diseases
Nose–brain axis
Olfactory bulb
Parkinson's disease
title Understanding the nose–brain axis and its role in related diseases: A conceptual review
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