Changes in the Dose–Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant

We considered, in general form for a 22 full factorial experiment, linear approximations of the organism’s dose–response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modificatio...

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Bibliographic Details
Published in:Dose-response 2016-12, Vol.14 (4), p.1559325816672935
Main Authors: Katsnelson, B. A., Panov, V. G., Varaksin, A. N., Minigalieva, I. A., Privalova, L. I., Sutunkova, M. P.
Format: Article
Language:English
Subjects:
Animal research
Factorial experiments
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Summary:We considered, in general form for a 22 full factorial experiment, linear approximations of the organism’s dose–response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modifications is suggested. An analysis of the outcomes obtained in a number of subchronic animal experiments on rats in which this response was assessed by changes in a large number of biomedical indices revealed that all theoretically possible variants (types) of the modification under consideration are actually observed depending on a specific index and specific harmful exposure. Statistical significance estimation procedures are formulated for each of them.
ISSN:1559-3258
1559-3258
DOI:10.1177/1559325816672935