A dynamic nomogram for predicting pathologic complete response to neoadjuvant chemotherapy in locally advanced rectal cancer

• Published in: Cancer medicine (Malden, MA) MA), 2024-06, Vol.13 (11), p.e7251-n/a
• Main Authors: Wang, Guancong, Li, Jiasen, Huang, Ying, Guo, Yincong
• Format: Article
• Language: English
• Subjects: Abbreviations; Adult; Aged; Cancer; Cancer therapies; Carbohydrates; Chemoradiotherapy; Chemotherapy; Colorectal cancer; dynamic nomogram; Female; Histopathology; Hospitals; Humans; locally advanced rectal cancer; Lymphatic system; Magnetic resonance imaging; Male; Middle Aged; neoadjuvant chemoradiotherapy; Neoadjuvant Therapy - methods; Neoplasm Staging; Nomograms; Pathologic Complete Response; pathological complete response; Patients; Radiation therapy; Rectal Neoplasms - diagnostic imaging; Rectal Neoplasms - drug therapy; Rectal Neoplasms - mortality; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Rectum; Regression analysis; Retrospective Studies; Surgery; total mesorectal excision; Treatment Outcome
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.7251

Aim To explore the clinical factors associated with pathologic complete response (pCR) for locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT) and develop a web‐based dynamic nomogram. Methods Retrospective analysis of patients with examination confirmed LARC from 2011 to 2022. Patients from the Union Hospital of Fujian Medical University were included as the training cohort (n = 1579) and Zhangzhou Hospital of Fujian Medical University as the external validation cohort (n = 246). Results In the training cohort, after nCRT, 350 (22.2%) patients achieved pCR. More stomas were avoided in pCR patients (73.9% vs. 69.7%, p = 0.043). After a median follow‐up time of 47.7 months (IQR 2–145) shown OS (5‐year: 93.7% vs. 81.0%, HR = 0.310, 95%CI: 0.189–0.510, p