Regulatory mechanism of macrophage polarization based on Hippo pathway

Macrophages are found to infiltrate and migrate in a large number of Tumor-associated macrophages (TMEs) and other macrophages in the microenvironment of tumors and related diseases, and undergo phenotypic changes in response to a variety of cytokines, mainly including the primary phenotype M2 and t...

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Bibliographic Details
Published in:Frontiers in immunology 2023-11, Vol.14, p.1279591-1279591
Main Authors: Liu, Yuanqing, An, Yina, Li, Gebin, Wang, Shuaiyu
Format: Article
Language:English
Subjects:
Cytokines - metabolism
Hippo
Hippo Signaling Pathway
Humans
Immunology
Macrophages
Neoplasms
Phenotype
polarization
regulation
Tumor Microenvironment
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Summary:Macrophages are found to infiltrate and migrate in a large number of Tumor-associated macrophages (TMEs) and other macrophages in the microenvironment of tumors and related diseases, and undergo phenotypic changes in response to a variety of cytokines, mainly including the primary phenotype M2 and the anti-tumor phenotype M1. The Hippo signaling pathway affects the development of cancer and other diseases through various biological processes, such as inhibition of cell growth. In this review, we focus on immune cells within the microenvironment of tumors and other diseases, and the role of the Hippo pathway in tumors on macrophage polarization in the tumor microenvironment (TME) and other diseases.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1279591