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Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients
OBJETIVO: Comparar el rendimiento en tareas de función ejecutiva (FE) en sujetos con enfermedad de Parkinson (EP) leve a moderada (Hoehn y Yahr
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| Published in: | Arquivos de neuro-psiquiatria 2006-09, Vol.64 (3b), p.814-823 |
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| container_title | Arquivos de neuro-psiquiatria |
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| creator | Carlos G. Abel Gustavo Stein Silvia Pereyra Gabriela Ñano Tomoko Arakaki Nélida Garretto Carlos Mangone Osvaldo Genovese Roberto E.P. Sica |
| description | OBJETIVO: Comparar el rendimiento en tareas de función ejecutiva (FE) en sujetos con enfermedad de Parkinson (EP) leve a moderada (Hoehn y Yahr |
| doi_str_mv | 10.1590/S0004-282X2006000500021 |
| format | article |
| fullrecord | <record><control><sourceid>doaj</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_ac8271ba0f5d4f829db4431cb06165e8</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_ac8271ba0f5d4f829db4431cb06165e8</doaj_id><sourcerecordid>oai_doaj_org_article_ac8271ba0f5d4f829db4431cb06165e8</sourcerecordid><originalsourceid>FETCH-doaj_primary_oai_doaj_org_article_ac8271ba0f5d4f829db4431cb06165e83</originalsourceid><addsrcrecordid>eNqtTrtOAzEQtBBIhMc3sB1VwHbuWUdB0EWCgu60Z-9FPu7sk31B5N8pcA4CoqGiWHk9MzszjF0JfiPSkt8-cs6TuSzks-Q8i580jhRHbCayvJgnUubHbPYtOmVnIbRRkZRlPmPvqzButXGgXD-gx9G8OtAEHQZotlYZZykAtaS2kYog2dETDKhM3CKlnI1YQ74njXp_ukb_YmyI-O4v3YYsTXkIijzV1LmAsJxqmP31vtgOXAP09plOU6MxVgpg7E_OdQBtAmEgQPvLmg7WHfqDJqqHyMVW4YKdNNgFuvx6z9nD3eppeT_XDttq8KZHv6scmmoCnN9U6EejOqpQFTIXNfIm1UlTyFLXSbIQquaZyFIqFv_p9QFrcaMR</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients</title><source>SciELO Brazil</source><creator>Carlos G. Abel ; Gustavo Stein ; Silvia Pereyra ; Gabriela Ñano ; Tomoko Arakaki ; Nélida Garretto ; Carlos Mangone ; Osvaldo Genovese ; Roberto E.P. Sica</creator><creatorcontrib>Carlos G. Abel ; Gustavo Stein ; Silvia Pereyra ; Gabriela Ñano ; Tomoko Arakaki ; Nélida Garretto ; Carlos Mangone ; Osvaldo Genovese ; Roberto E.P. Sica</creatorcontrib><description>OBJETIVO: Comparar el rendimiento en tareas de función ejecutiva (FE) en sujetos con enfermedad de Parkinson (EP) leve a moderada (Hoehn y Yahr <3) no dementes y en sujetos con enfermedad degenerativa cerebelosa pura (EC), a fin de evaluar el eventual rol diferencial de los ganglios basales y el cerebelo en esa función. MÉTODO: Se evaluaron 14 pacientes con EP y 14 con EC apareados por sexo, educación, duración de enfermedad y MMSE, mediante tests neuropsicológicos estándar y el test de Wisconsin [WCST]). Se compararon puntajes Z promedio de cada grupo mediante prueba de "t" para muestras independientes. RESULTADOS: El grupo EC rindió significativamente menos en pruebas de atención y FE presentando errores perseverativos y no perseverativos durante el WCST. El grupo EP mostró aumento significativo de errores no perseverativos en relación al estándar esperado, sin alcanzar diferencias significativas con el grupo EC. CONCLUSIÓN: el grupo EC mostró defectos significativamente mayores en tareas de FE exhibiendo un patrón de disfunción prefrontal.OBJECTIVE: To compare executive functions (EF) in non-demented mild to moderate Parkinson's disease (PD) (Hoehn and Yahr <3) and pure degenerative cerebellar disease (CD) in order to evaluate the relative contribution and differential role of basal ganglia and cerebellum in those functions. METHOD: 14 patients with PD and 14 patients with CD matched by sex, education, disease's duration and MMSE were selected. A standardized neuropsychological battery and the Wisconsin Card Sorting Test (WCST) were administered. Z scores were compared for both groups through t-test for independent samples were used. RESULTS: The cerebellar group showed significant lower performance in measures of attention and EF, with a significant increase in both perseverative and non perseverative errors during the WCST. On the other hand the PD group showed a selective increase of non perseverative errors, without reaching significant between group difference. CONCLUSION: The CD group appears to have greater deficits in EF with a pattern of prefrontal dysfunction.</description><identifier>ISSN: 0004-282X</identifier><identifier>EISSN: 1678-4227</identifier><identifier>DOI: 10.1590/S0004-282X2006000500021</identifier><language>eng</language><publisher>Academia Brasileira de Neurologia (ABNEURO)</publisher><subject>basal ganglia ; cerebellum ; cerebelo ; cognición ; cognition ; disfunción ejecutiva ; enfermedad de Parkinson ; executive dysfunction ; ganglios basales ; Parkinson's disease ; test de Wisconsin ; Wisconsin test</subject><ispartof>Arquivos de neuro-psiquiatria, 2006-09, Vol.64 (3b), p.814-823</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Carlos G. Abel</creatorcontrib><creatorcontrib>Gustavo Stein</creatorcontrib><creatorcontrib>Silvia Pereyra</creatorcontrib><creatorcontrib>Gabriela Ñano</creatorcontrib><creatorcontrib>Tomoko Arakaki</creatorcontrib><creatorcontrib>Nélida Garretto</creatorcontrib><creatorcontrib>Carlos Mangone</creatorcontrib><creatorcontrib>Osvaldo Genovese</creatorcontrib><creatorcontrib>Roberto E.P. Sica</creatorcontrib><title>Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients</title><title>Arquivos de neuro-psiquiatria</title><description>OBJETIVO: Comparar el rendimiento en tareas de función ejecutiva (FE) en sujetos con enfermedad de Parkinson (EP) leve a moderada (Hoehn y Yahr <3) no dementes y en sujetos con enfermedad degenerativa cerebelosa pura (EC), a fin de evaluar el eventual rol diferencial de los ganglios basales y el cerebelo en esa función. MÉTODO: Se evaluaron 14 pacientes con EP y 14 con EC apareados por sexo, educación, duración de enfermedad y MMSE, mediante tests neuropsicológicos estándar y el test de Wisconsin [WCST]). Se compararon puntajes Z promedio de cada grupo mediante prueba de "t" para muestras independientes. RESULTADOS: El grupo EC rindió significativamente menos en pruebas de atención y FE presentando errores perseverativos y no perseverativos durante el WCST. El grupo EP mostró aumento significativo de errores no perseverativos en relación al estándar esperado, sin alcanzar diferencias significativas con el grupo EC. CONCLUSIÓN: el grupo EC mostró defectos significativamente mayores en tareas de FE exhibiendo un patrón de disfunción prefrontal.OBJECTIVE: To compare executive functions (EF) in non-demented mild to moderate Parkinson's disease (PD) (Hoehn and Yahr <3) and pure degenerative cerebellar disease (CD) in order to evaluate the relative contribution and differential role of basal ganglia and cerebellum in those functions. METHOD: 14 patients with PD and 14 patients with CD matched by sex, education, disease's duration and MMSE were selected. A standardized neuropsychological battery and the Wisconsin Card Sorting Test (WCST) were administered. Z scores were compared for both groups through t-test for independent samples were used. RESULTS: The cerebellar group showed significant lower performance in measures of attention and EF, with a significant increase in both perseverative and non perseverative errors during the WCST. On the other hand the PD group showed a selective increase of non perseverative errors, without reaching significant between group difference. CONCLUSION: The CD group appears to have greater deficits in EF with a pattern of prefrontal dysfunction.</description><subject>basal ganglia</subject><subject>cerebellum</subject><subject>cerebelo</subject><subject>cognición</subject><subject>cognition</subject><subject>disfunción ejecutiva</subject><subject>enfermedad de Parkinson</subject><subject>executive dysfunction</subject><subject>ganglios basales</subject><subject>Parkinson's disease</subject><subject>test de Wisconsin</subject><subject>Wisconsin test</subject><issn>0004-282X</issn><issn>1678-4227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqtTrtOAzEQtBBIhMc3sB1VwHbuWUdB0EWCgu60Z-9FPu7sk31B5N8pcA4CoqGiWHk9MzszjF0JfiPSkt8-cs6TuSzks-Q8i580jhRHbCayvJgnUubHbPYtOmVnIbRRkZRlPmPvqzButXGgXD-gx9G8OtAEHQZotlYZZykAtaS2kYog2dETDKhM3CKlnI1YQ74njXp_ukb_YmyI-O4v3YYsTXkIijzV1LmAsJxqmP31vtgOXAP09plOU6MxVgpg7E_OdQBtAmEgQPvLmg7WHfqDJqqHyMVW4YKdNNgFuvx6z9nD3eppeT_XDttq8KZHv6scmmoCnN9U6EejOqpQFTIXNfIm1UlTyFLXSbIQquaZyFIqFv_p9QFrcaMR</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Carlos G. Abel</creator><creator>Gustavo Stein</creator><creator>Silvia Pereyra</creator><creator>Gabriela Ñano</creator><creator>Tomoko Arakaki</creator><creator>Nélida Garretto</creator><creator>Carlos Mangone</creator><creator>Osvaldo Genovese</creator><creator>Roberto E.P. Sica</creator><general>Academia Brasileira de Neurologia (ABNEURO)</general><scope>DOA</scope></search><sort><creationdate>20060901</creationdate><title>Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients</title><author>Carlos G. Abel ; Gustavo Stein ; Silvia Pereyra ; Gabriela Ñano ; Tomoko Arakaki ; Nélida Garretto ; Carlos Mangone ; Osvaldo Genovese ; Roberto E.P. Sica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-doaj_primary_oai_doaj_org_article_ac8271ba0f5d4f829db4431cb06165e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>basal ganglia</topic><topic>cerebellum</topic><topic>cerebelo</topic><topic>cognición</topic><topic>cognition</topic><topic>disfunción ejecutiva</topic><topic>enfermedad de Parkinson</topic><topic>executive dysfunction</topic><topic>ganglios basales</topic><topic>Parkinson's disease</topic><topic>test de Wisconsin</topic><topic>Wisconsin test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlos G. Abel</creatorcontrib><creatorcontrib>Gustavo Stein</creatorcontrib><creatorcontrib>Silvia Pereyra</creatorcontrib><creatorcontrib>Gabriela Ñano</creatorcontrib><creatorcontrib>Tomoko Arakaki</creatorcontrib><creatorcontrib>Nélida Garretto</creatorcontrib><creatorcontrib>Carlos Mangone</creatorcontrib><creatorcontrib>Osvaldo Genovese</creatorcontrib><creatorcontrib>Roberto E.P. Sica</creatorcontrib><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlos G. Abel</au><au>Gustavo Stein</au><au>Silvia Pereyra</au><au>Gabriela Ñano</au><au>Tomoko Arakaki</au><au>Nélida Garretto</au><au>Carlos Mangone</au><au>Osvaldo Genovese</au><au>Roberto E.P. Sica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><date>2006-09-01</date><risdate>2006</risdate><volume>64</volume><issue>3b</issue><spage>814</spage><epage>823</epage><pages>814-823</pages><issn>0004-282X</issn><eissn>1678-4227</eissn><abstract>OBJETIVO: Comparar el rendimiento en tareas de función ejecutiva (FE) en sujetos con enfermedad de Parkinson (EP) leve a moderada (Hoehn y Yahr <3) no dementes y en sujetos con enfermedad degenerativa cerebelosa pura (EC), a fin de evaluar el eventual rol diferencial de los ganglios basales y el cerebelo en esa función. MÉTODO: Se evaluaron 14 pacientes con EP y 14 con EC apareados por sexo, educación, duración de enfermedad y MMSE, mediante tests neuropsicológicos estándar y el test de Wisconsin [WCST]). Se compararon puntajes Z promedio de cada grupo mediante prueba de "t" para muestras independientes. RESULTADOS: El grupo EC rindió significativamente menos en pruebas de atención y FE presentando errores perseverativos y no perseverativos durante el WCST. El grupo EP mostró aumento significativo de errores no perseverativos en relación al estándar esperado, sin alcanzar diferencias significativas con el grupo EC. CONCLUSIÓN: el grupo EC mostró defectos significativamente mayores en tareas de FE exhibiendo un patrón de disfunción prefrontal.OBJECTIVE: To compare executive functions (EF) in non-demented mild to moderate Parkinson's disease (PD) (Hoehn and Yahr <3) and pure degenerative cerebellar disease (CD) in order to evaluate the relative contribution and differential role of basal ganglia and cerebellum in those functions. METHOD: 14 patients with PD and 14 patients with CD matched by sex, education, disease's duration and MMSE were selected. A standardized neuropsychological battery and the Wisconsin Card Sorting Test (WCST) were administered. Z scores were compared for both groups through t-test for independent samples were used. RESULTS: The cerebellar group showed significant lower performance in measures of attention and EF, with a significant increase in both perseverative and non perseverative errors during the WCST. On the other hand the PD group showed a selective increase of non perseverative errors, without reaching significant between group difference. CONCLUSION: The CD group appears to have greater deficits in EF with a pattern of prefrontal dysfunction.</abstract><pub>Academia Brasileira de Neurologia (ABNEURO)</pub><doi>10.1590/S0004-282X2006000500021</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Arquivos de neuro-psiquiatria, 2006-09, Vol.64 (3b), p.814-823 |
| issn | 0004-282X 1678-4227 |
| language | eng |
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| source | SciELO Brazil |
| subjects | basal ganglia cerebellum cerebelo cognición cognition disfunción ejecutiva enfermedad de Parkinson executive dysfunction ganglios basales Parkinson's disease test de Wisconsin Wisconsin test |
| title | Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients |
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