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Correlates of insulin clearance in apparently healthy non-obese Japanese men
Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI
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| Published in: | Scientific reports 2017-05, Vol.7 (1), p.1462-8, Article 1462 |
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| creator | Kaga, Hideyoshi Tamura, Yoshifumi Takeno, Kageumi Kakehi, Saori Funayama, Takashi Furukawa, Yasuhiko Nishitani-Yokoyama, Miho Shimada, Kazunori Daida, Hiroyuki Aoki, Shigeki Giacca, Adria Kanazawa, Akio Kawamori, Ryuzo Watada, Hirotaka |
| description | Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI |
| doi_str_mv | 10.1038/s41598-017-01469-x |
| format | article |
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2
), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SS
SI
) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SS
SI
in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO
2peak
and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-01469-x</identifier><identifier>PMID: 28469173</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/2037 ; 692/163/2743/2815 ; Adipose tissue ; Adipose Tissue - metabolism ; Adult ; Blood Glucose - metabolism ; Body fat ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Fitness ; Glucose ; Glucose Clamp Technique ; Health risks ; Healthy Volunteers ; Humanities and Social Sciences ; Humans ; Hyperinsulinemia ; Hyperinsulinism - blood ; Hyperinsulinism - pathology ; Insulin ; Insulin - blood ; Insulin Resistance ; Male ; Metabolism ; Middle Aged ; multidisciplinary ; Obesity - blood ; Obesity - pathology ; Prospective Studies ; Risk factors ; Science ; Science (multidisciplinary) ; Triglycerides - blood</subject><ispartof>Scientific reports, 2017-05, Vol.7 (1), p.1462-8, Article 1462</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group May 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-a4592b97d6042416c89db400dd4264330764220822a73cb5d721d67e486c1e9a3</citedby><cites>FETCH-LOGICAL-c690t-a4592b97d6042416c89db400dd4264330764220822a73cb5d721d67e486c1e9a3</cites><orcidid>0000-0001-5405-9292 ; 0000-0003-2292-395X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1962327775/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1962327775?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772,74873</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28469173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaga, Hideyoshi</creatorcontrib><creatorcontrib>Tamura, Yoshifumi</creatorcontrib><creatorcontrib>Takeno, Kageumi</creatorcontrib><creatorcontrib>Kakehi, Saori</creatorcontrib><creatorcontrib>Funayama, Takashi</creatorcontrib><creatorcontrib>Furukawa, Yasuhiko</creatorcontrib><creatorcontrib>Nishitani-Yokoyama, Miho</creatorcontrib><creatorcontrib>Shimada, Kazunori</creatorcontrib><creatorcontrib>Daida, Hiroyuki</creatorcontrib><creatorcontrib>Aoki, Shigeki</creatorcontrib><creatorcontrib>Giacca, Adria</creatorcontrib><creatorcontrib>Kanazawa, Akio</creatorcontrib><creatorcontrib>Kawamori, Ryuzo</creatorcontrib><creatorcontrib>Watada, Hirotaka</creatorcontrib><title>Correlates of insulin clearance in apparently healthy non-obese Japanese men</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m
2
), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SS
SI
) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SS
SI
in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO
2peak
and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.</description><subject>692/163/2743/2037</subject><subject>692/163/2743/2815</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Body fat</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Fitness</subject><subject>Glucose</subject><subject>Glucose Clamp Technique</subject><subject>Health risks</subject><subject>Healthy Volunteers</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperinsulinemia</subject><subject>Hyperinsulinism - blood</subject><subject>Hyperinsulinism - pathology</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Obesity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaga, Hideyoshi</au><au>Tamura, Yoshifumi</au><au>Takeno, Kageumi</au><au>Kakehi, Saori</au><au>Funayama, Takashi</au><au>Furukawa, Yasuhiko</au><au>Nishitani-Yokoyama, Miho</au><au>Shimada, Kazunori</au><au>Daida, Hiroyuki</au><au>Aoki, Shigeki</au><au>Giacca, Adria</au><au>Kanazawa, Akio</au><au>Kawamori, Ryuzo</au><au>Watada, Hirotaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlates of insulin clearance in apparently healthy non-obese Japanese men</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-05-03</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>1462</spage><epage>8</epage><pages>1462-8</pages><artnum>1462</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m
2
), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SS
SI
) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SS
SI
in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO
2peak
and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28469173</pmid><doi>10.1038/s41598-017-01469-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5405-9292</orcidid><orcidid>https://orcid.org/0000-0003-2292-395X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Full-Text Journals in Chemistry (Open access); Publicly Available Content (ProQuest); PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 692/163/2743/2037 692/163/2743/2815 Adipose tissue Adipose Tissue - metabolism Adult Blood Glucose - metabolism Body fat Cholesterol, HDL - blood Cholesterol, LDL - blood Fitness Glucose Glucose Clamp Technique Health risks Healthy Volunteers Humanities and Social Sciences Humans Hyperinsulinemia Hyperinsulinism - blood Hyperinsulinism - pathology Insulin Insulin - blood Insulin Resistance Male Metabolism Middle Aged multidisciplinary Obesity - blood Obesity - pathology Prospective Studies Risk factors Science Science (multidisciplinary) Triglycerides - blood |
| title | Correlates of insulin clearance in apparently healthy non-obese Japanese men |
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