Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more...

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Bibliographic Details
Published in:Cardiovascular therapeutics 2022-03, Vol.2022, p.4559809-23
Main Authors: He, Jinshan, Li, Sicong, Ding, Yumeng, Tong, Yujia, Li, Xuebin
Format: Article
Language:English
Subjects:
Ablation
Anti-Arrhythmia Agents - adverse effects
Apoptosis
Atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - drug therapy
Biological Products - adverse effects
Cardiac arrhythmia
Cardiomyocytes
Catheters
Genes
Health aspects
Heart attack
Heart failure
Heart Failure - drug therapy
Humans
Ibutilide
Ion channels
Ion Channels - therapeutic use
Kinases
Medical prognosis
Natural products
Pacemakers
Potassium
Quality of life
R&D
Research & development
Review
Signal transduction
Sinuses
Sodium
Thoracic surgery
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Summary:Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed. Active components extracted from natural products are potential choices for AF therapy. Natural products like Panax notoginseng (Burk.) F.H. Chen, Sophora flavescens Ait., Stephania tetrandra S. Moore., Pueraria lobata (Willd.) Ohwi var. thomsonii (Benth.) Vaniot der Maesen., and Coptis chinensis Franch. have a long history in the treatment of arrhythmia, myocardial infarction, stroke, and heart failure in China. Based on the classification of chemical structures, this article discussed the natural product components’ therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes, in order to provide a reference for development of therapeutic drugs for atrial fibrillation.
ISSN:1755-5914
1755-5922
DOI:10.1155/2022/4559809