Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry

Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variabili...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-08, Vol.21 (9), p.1120
Main Authors: Feliciano, Rodrigo P, Istas, Geoffrey, Heiss, Christian, Rodriguez-Mateos, Ana
Format: Article
Language:English
Subjects:
(poly)phenols
acute
Adolescent
Adult
Aged
blueberry
Blueberry Plants
chronic
Double-Blind Method
Eating
Fruit
Gastrointestinal Microbiome - physiology
Humans
inter-individual variability
Male
Middle Aged
plasma
Polyphenols - blood
Polyphenols - urine
urine
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Summary:Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at baseline and 2 h post-consumption on day 1 and day 30. Twenty-four-hour urine was also collected on both days. A total of 61 phenolic metabolites were quantified in plasma at baseline, of which 43 increased after acute or chronic consumption of blueberries over one month. Benzoic and catechol derivatives represented more than 80% of the changes in phenolic profile after 2 h consumption on day 1, whereas hippuric and benzoic derivatives were the major compounds that increased at 0 and 2 h on day 30, respectively. The total (poly)phenol urinary excretion remained unchanged after 30 days of wild blueberry intake. The inter-individual variability ranged between 40%-48% in plasma and 47%-54% in urine. Taken together, our results illustrate that blueberry (poly)phenols are absorbed and extensively metabolized by phase II enzymes and by the gut microbiota, leading to a whole array of metabolites that may be responsible for the beneficial effects observed after blueberry consumption.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21091120