Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes

Background Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) is a simple measurement associated with inflammation and oxid...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2021-07, Vol.21 (1), p.1-362, Article 362
Main Authors: Mayasari, Dyah Samti, Taufiq, Nahar, Hariawan, Hariadi
Format: Article
Language:English
Subjects:
Ankle
Arterial occlusions
Arterial stiffness
Biomarkers
Blood pressure
Body mass index
Cardio ankle vascular index
Cardiovascular disease
Cholesterol
Collagen (type I)
Complications and side effects
Coronary vessels
Correlation analysis
Cytokines
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetic retinopathy
Diagnosis
Elastin
Fasting
Glucose
Health aspects
High density lipoprotein
High density lipoproteins
Hospitals
Hypertension
Inflammation
Inflammation biomarkers
Kidney diseases
Laboratories
Measurement
Medical records
Monocyte-to-HDL ratio
Monocytes
Multivariate analysis
Normal distribution
Oxidative stress
Patients
Regression analysis
Risk factors
Statins
Statistical analysis
Type 2 diabetes
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Summary:Background Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) is a simple measurement associated with inflammation and oxidative stress. However, little is known about the relationship of MHR with arterial stiffness. This study aimed to determine the association of MHR with arterial stiffness in patients with diabetes. Methods A total of 81 patients with type 2 diabetes mellitus were enrolled in a cross-sectional study. Arterial stiffness factor in this study was Cardio Ankle Vascular Index (CAVI). We analyzed complete blood count and lipid profile in all participants, then performed statistical analysis to determine the relationship between MHR and CAVI. Receiver operating characteristic (ROC) analysis was used to estimate the cut-off values of MHR to predict CAVI [greater than or equai to] 9. Results Median of MHR in this study was 11.91 with the mean of CAVI was 8.13 [+ or -] 0.93. Spearman correlation analysis revealed a significant positive correlation between MHR and CAVI ([rho] = 0.239, p = 0.031). Multivariate analysis showed the independent association of MHR to arterial stiffness ([beta] = 0.361, 95% CI 0.023-0.093) and to CAVI [greater than or equai to] 9 (OR 1.181, 95% CI 1.047-1.332). The cut-off values of MHR for predicting CAVI [greater than or equai to] 9 were identified as [greater than or equai to] 13 (OR 3.289, 95% CI 1.036-10.441). Conclusion MHR is associated with CAVI in patients with diabetes, irrespective of various potential confounders. Keywords: Monocyte-to-HDL ratio, Cardio ankle vascular index, Arterial stiffness, Inflammation biomarkers, Diabetes
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-021-02180-6