Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia

About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied. In addition, markers for spermatogonia in testis...

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Published in:Life (Basel, Switzerland) Switzerland), 2023-02, Vol.13 (3), p.616
Main Authors: Willems, Margo, Devriendt, Céline, Olsen, Catharina, Caljon, Ben, Janssen, Toon, Gies, Inge, Vloeberghs, Veerle, Tournaye, Herman, Van Saen, Dorien, Goossens, Ellen
Format: Article
Language:English
Subjects:
Alcohol
Analysis
Antigens
Biological markers
Biomarkers
Biopsy
Communication
Fertility
Klinefelter's syndrome
Medical research
Medicine, Experimental
MicroRNA
MicroRNAs
non-obstructive azoospermia
Patients
Plasma
Semen
Sperm
Spermatogenesis
Spermatogonia
Spermatozoa
Testes
Urine
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Summary:About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied. In addition, markers for spermatogonia in testis tissue were explored. This study aimed to find biomarkers in the semen and/or urine of NOA patients to predict the presence of spermatogonia in the testis. Differentially expressed miRNAs were identified (1) between samples from patients with and without a positive TESE procedure as well as (2) between TESE-negative patients with and without spermatogonia. A total of thirteen upregulated miRNAs (ten in seminal plasma and three in urine) were found in the TESE-negative/spermatogonia-positive group compared to the TESE-negative/spermatogonia-negative group. These miRNAs could be potential biomarkers for spermatogonia; however, more research is necessary to validate their predictive power.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13030616