Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy

Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over the past decades, it is acceptable to admit that these are expensive, invasive, associated with many side effects and, therefore, a reduced quality of life. One of the most p...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-09, Vol.20 (19), p.4771
Main Authors: R Mokoena, Dimakatso, P George, Blassan, Abrahamse, Heidi
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - chemistry
Apoptosis
Breast cancer
breast cancer therapy
Breast Neoplasms - therapy
Cancer therapies
Cannabidiol
cannabidiol (cbd)
Cannabidiol - administration & dosage
Cannabidiol - chemistry
Cannabinoids
Cannabis
Combined Modality Therapy
Drug delivery systems
Female
Gold
Gold - chemistry
gold nanoparticle (aunp)
Humans
Immunology
Invasiveness
Metal Nanoparticles - chemistry
Nanoparticles
Perylene - administration & dosage
Perylene - analogs & derivatives
Photochemotherapy - methods
Photodynamic therapy
photodynamic therapy (pdt)
Photosensitizing Agents - administration & dosage
Quality of life
Review
Side effects
Treatment Outcome
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Summary:Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over the past decades, it is acceptable to admit that these are expensive, invasive, associated with many side effects and, therefore, a reduced quality of life. One of the most possible solutions to this could be the use of gold nanoparticle (AuNP) conjugated photodynamic therapy (PDT) in combination with cannabidiol (CBD), a derivative from the . Since the use of has always been associated with recreation and psychoactive qualities, the positive effects of or its derivatives on cancer treatment have been misunderstood and hence misinterpreted. On the other hand, AuNP-PDT is the most favoured form of treatment for cancer, due to its augmented specificity and minimal risk of side effects compared to conventional treatments. However, its use requires the consideration of several physical, biologic, pharmacologic and immunological factors, which may hinder its effectiveness if not taken into consideration. In this review, the role of gold nanoparticle mediated PDT combined with CBD treatment on breast cancer cells will be deliberated.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20194771