Magnetic capture device for large volume sample analysis

Immunomagnetic separation (IMS) techniques employing superparamagnetic particles can successfully isolate various components from mixtures. However, their utility can be limited for large-volume samples, viscous samples, or those containing a high density of particulate matter because of the need to...

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Bibliographic Details
Published in:PloS one 2024-02, Vol.19 (2), p.e0297806-e0297806
Main Authors: Armstrong, Cheryl M, Capobianco, Joseph A, Lee, Joe
Format: Article
Language:English
Subjects:
Analysis
Composition
Environmental aspects
Ethylenediaminetetraacetic acid
Immunomagnetic Separation - methods
Magnetic materials
Magnetic Phenomena
Magnetics
Magnets
Particle flow
Particles
Properties
Scientific equipment and supplies industry
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Summary:Immunomagnetic separation (IMS) techniques employing superparamagnetic particles can successfully isolate various components from mixtures. However, their utility can be limited for large-volume samples, viscous samples, or those containing a high density of particulate matter because of the need to generate high field gradients for particle recovery. Therefore, a new class of immunomagnetic particles was devised utilizing a single, macroscopic Pyrex spinbar conjugated with biorecognition elements to address these limitations. Advantages include an inherent capacity for effective mixing, an almost instantaneous recovery of the spinbar that can be performed without expensive equipment and with no loss of magnetic particles during processing, and reduced transfer of sample matrix. As a result, spinbars can provide an effective means for IMS with large-volume assays composed of complex matrices.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0297806